{"id":49717,"date":"2026-04-28T11:22:15","date_gmt":"2026-04-28T08:22:15","guid":{"rendered":"https:\/\/arsco.org\/?post_type=articles&#038;p=49717"},"modified":"2026-04-28T11:22:15","modified_gmt":"2026-04-28T08:22:15","slug":"%d8%b9%d9%86%d8%af%d9%85%d8%a7-%d8%aa%d8%aa%d8%ad%d9%83%d9%85-%d8%a7%d9%84%d9%81%d9%8a%d8%b2%d9%8a%d8%a7%d8%a1-%d9%81%d9%8a-%d8%a7%d9%84%d8%ac%d9%8a%d9%86%d8%a7%d8%aa","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-49717\/","title":{"rendered":"\u0639\u0646\u062f\u0645\u0627 \u062a\u062a\u062d\u0643\u0645 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a"},"content":{"rendered":"<p><span style=\"color: #ffffff;\">.<\/span><\/p>\n<p style=\"direction: rtl; text-align: justify;\" data-start=\"93\" data-end=\"634\"><span style=\"color: #008080;\">\u0641\u064a \u0645\u0627\u0631\u0633 2026\u060c \u0646\u064f\u0634\u0631\u062a <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10255-7\">\u0648\u0631\u0642\u0629 \u0639\u0644\u0645\u064a\u0629<\/a> \u0644\u0627\u0641\u062a\u0629 \u0628\u0639\u0646\u0648\u0627\u0646 \u201cStructural basis of supercoiling-induced CRISPR\u2013Cas9 off-target activity\u201d \u0641\u064a \u0645\u062c\u0644\u0629 Nature\u060c \u0628\u0625\u0634\u0631\u0627\u0641 \u0641\u0631\u064a\u0642 \u0628\u062d\u062b\u064a \u062f\u0648\u0644\u064a\u060c \u0648\u0634\u0627\u0631\u0643 \u0641\u064a\u0647 \u0628\u0627\u062d\u062b\u0648\u0646 \u0645\u0646 \u062a\u062e\u0635\u0635\u0627\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629\u060c \u0648\u0645\u0646 \u0628\u064a\u0646\u0647\u0645 \u0628\u0627\u062d\u062b\u0648\u0646 \u0645\u0646 \u062e\u0644\u0641\u064a\u0627\u062a \u0639\u0631\u0628\u064a\u0629 \u064a\u0639\u0645\u0644\u0648\u0646 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data-start=\"1661\" data-end=\"2138\"><span style=\"color: #800080;\">\u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0642\u064a\u0627\u0633 \u064a\u0639\u0643\u0633 \u0643\u064a\u0641 \u0623\u0635\u0628\u062d\u062a \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0623\u062f\u0627\u0629 \u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0641\u0647\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u0632\u064a\u0626\u064a.<\/span><\/p>\n<p style=\"direction: rtl; text-align: justify;\" data-start=\"2140\" data-end=\"2571\">\u062a\u0642\u062f\u0645 \u0627\u0644\u0648\u0631\u0642\u0629 \u0623\u064a\u0636\u064b\u0627 \u0625\u0637\u0627\u0631\u064b\u0627 \u0646\u0638\u0631\u064a\u064b\u0627 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0645\u0641\u0627\u0647\u064a\u0645 \u0645\u0646 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 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data-end=\"3105\">\u062a\u062a\u062c\u0627\u0648\u0632 \u0623\u0647\u0645\u064a\u0629 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0646\u0638\u0631\u064a\u060c \u0625\u0630 \u062a\u0641\u062a\u062d \u0622\u0641\u0627\u0642\u064b\u0627 \u062c\u062f\u064a\u062f\u0629 \u0641\u064a \u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629. \u0641\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0628\u064a\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u0641\u0647\u0645 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0625\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u062c\u062f\u064a\u062f\u0629 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\u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0635\u0646\u0627\u0639\u064a\u060c \u0641\u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0644\u062a\u0635\u0645\u064a\u0645 \u0643\u0627\u0626\u0646\u0627\u062a \u062f\u0642\u064a\u0642\u0629 \u0645\u062d\u0633\u0651\u0646\u0629\u060c \u062d\u064a\u062b \u064a\u062a\u0645 \u0627\u0644\u062a\u062d\u0643\u0645 \u0644\u064a\u0633 \u0641\u0642\u0637 \u0641\u064a \u062c\u064a\u0646\u0627\u062a\u0647\u0627\u060c \u0628\u0644 \u0641\u064a \u062d\u0627\u0644\u062a\u0647\u0627 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0623\u064a\u0636\u064b\u0627 \u0644\u062a\u062d\u0642\u064a\u0642 \u0623\u062f\u0627\u0621 \u0623\u0639\u0644\u0649.<\/p>\n<p style=\"direction: rtl; text-align: justify;\" data-start=\"3107\" data-end=\"3424\">\u0645\u0627 \u062a\u0643\u0634\u0641\u0647 \u0647\u0630\u0647 \u0627\u0644\u0648\u0631\u0642\u0629 \u0641\u064a \u062c\u0648\u0647\u0631\u0647 \u0647\u0648 \u0623\u0646 \u0627\u0644\u062d\u062f\u0648\u062f \u0628\u064a\u0646 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0648\u0627\u0644\u0623\u062d\u064a\u0627\u0621 \u0644\u0645 \u062a\u0639\u062f \u0642\u0627\u0626\u0645\u0629 \u0643\u0645\u0627 \u0643\u0627\u0646\u062a. \u0641\u0627\u0644\u062d\u064a\u0627\u0629\u060c \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u060c \u0647\u064a \u0646\u0638\u0627\u0645 \u0641\u064a\u0632\u064a\u0627\u0626\u064a \u064a\u062e\u0636\u0639 \u0644\u0642\u0648\u0627\u0646\u064a\u0646 \u0627\u0644\u0637\u0627\u0642\u0629 \u0648\u0627\u0644\u062d\u0631\u0643\u0629 \u0648\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644. \u0647\u0630\u0627 \u0627\u0644\u0641\u0647\u0645 \u0627\u0644\u062c\u062f\u064a\u062f \u064a\u0639\u064a\u062f \u062a\u0639\u0631\u064a\u0641 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0628\u0648\u0635\u0641\u0647\u0627 \u0639\u0644\u0645\u064b\u0627 \u0647\u062c\u064a\u0646\u064b\u0627\u060c \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062a\u0643\u0627\u0645\u0644 \u0628\u064a\u0646 \u0627\u0644\u062a\u062e\u0635\u0635\u0627\u062a\u060c \u0648\u064a\u0636\u0639 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0641\u064a \u0642\u0644\u0628 \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629.<\/p>\n<p style=\"direction: rtl; text-align: justify;\" data-start=\"3426\" data-end=\"3736\"><span style=\"color: #008080;\">\u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u0642\u0648\u0644 \u0625\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062a\u0645\u062b\u0644 \u062e\u0637\u0648\u0629 \u0645\u0647\u0645\u0629 \u0646\u062d\u0648 \u0645\u0627 \u064a\u0645\u0643\u0646 \u062a\u0633\u0645\u064a\u062a\u0647 \u0628\u0627\u0644\u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u062c\u064a\u0646\u0648\u0645\u060c \u062d\u064a\u062b \u0644\u0627 \u064a\u0642\u062a\u0635\u0631 \u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0645\u064a \u0639\u0644\u0649 \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0634\u064a\u0641\u0631\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629\u060c \u0628\u0644 \u064a\u0645\u062a\u062f \u0625\u0644\u0649 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a \u0627\u0644\u0628\u0646\u064a\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0634\u064a\u0641\u0631\u0629. \u0648\u0647\u0630\u0627 \u0627\u0644\u062a\u062d\u0648\u0644 \u0642\u062f \u064a\u0643\u0648\u0646 \u0647\u0648 \u0627\u0644\u0645\u0641\u062a\u0627\u062d \u0627\u0644\u062d\u0642\u064a\u0642\u064a \u0644\u0644\u062c\u064a\u0644 \u0627\u0644\u0642\u0627\u062f\u0645 \u0645\u0646 \u0627\u0644\u0627\u0628\u062a\u0643\u0627\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0637\u0628 \u0648\u0627\u0644\u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629.<\/span><\/p>\n<p dir=\"rtl\" style=\"text-align: justify;\"><span style=\"color: #ffffff;\">.<\/span><\/p>\n<p dir=\"rtl\" style=\"text-align: justify;\"><span style=\"color: #ff6600;\">\u0627\u0644\u0645\u0635\u0627\u062f\u0631<\/span><\/p>\n<p>Nature | <a href=\"http:\/\/www.nature.com\/articles\/s41586-026-10255-7\">https:\/\/www.nature.com\/articles\/s41586-026-10255-7<\/a><\/p>\n<p>Phys.org | <a href=\"https:\/\/phys.org\/news\/2026-03-dna-crucial-gene-therapy.html\">https:\/\/phys.org\/news\/2026-03-dna-crucial-gene-therapy.html<\/a><\/p>\n<p>Imperial College London | <a href=\"https:\/\/www.imperial.ac.uk\/news\/2026\/crispr-dna-structure-study\">https:\/\/www.imperial.ac.uk\/news\/2026\/crispr-dna-structure-study<\/a><\/p>\n<p><span style=\"color: #ffffff;\">.<\/span><\/p>\n<p dir=\"rtl\"><span style=\"color: #ff6600;\">\u062a\u0648\u0627\u0635\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u062a\u0628: <a href=\"mailto:drsamirabdulhamid@gmail.com\">drsamirabdulhamid@gmail.com<\/a><\/span><\/p>\n","protected":false},"featured_media":49724,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[15763,15762,6048,5898,7858],"class_list":["post-49717","articles","type-articles","status-publish","has-post-thumbnail","hentry","tag-15763","tag-15762","tag-tag-299","tag-tag-149","tag-tag-2109"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0639\u0646\u062f\u0645\u0627 \u062a\u062a\u062d\u0643\u0645 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a - ARSCO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsco.org\/en\/articles\/article-detail-49717\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0639\u0646\u062f\u0645\u0627 \u062a\u062a\u062d\u0643\u0645 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a - ARSCO\" \/>\n<meta property=\"og:description\" content=\". \u0641\u064a \u0645\u0627\u0631\u0633 2026\u060c \u0646\u064f\u0634\u0631\u062a \u0648\u0631\u0642\u0629 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