{"id":16340,"date":"2023-04-16T10:25:20","date_gmt":"2023-04-16T10:25:20","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-32315\/"},"modified":"2023-04-16T10:25:20","modified_gmt":"2023-04-16T10:25:20","slug":"article-detail-32315","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-16340\/","title":{"rendered":"\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0635\u064a\u0627\u0645 \u0641\u064a \u0623\u064a\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629"},"content":{"rendered":"

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(autophagy) \u0644\u0645\u062e\u0644\u0641\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0636\u0627\u0631\u0629 \u0628\u0627\u0644\u062c\u0633\u0645\u060c \u0648\u0647\u0630\u0627 \u0641\u0636\u0644\u064c \u0645\u0646 \u0623\u0641\u0636\u0627\u0644 \u0627\u0644\u0635\u064a\u0627\u0645. \u0648\u0645\u0646 \u062c\u0647\u0629\u064d \u0623\u062e\u0631\u0649 \u0648\u064f\u062c\u062f \u0628\u0623\u0646 \u0627\u0644\u0635\u064a\u0627\u0645 \u064a\u064f\u062d\u0633\u0651\u0646 \u0645\u0646 \u0623\u064a\u0636 \u0627\u0644\u062c\u0633\u0645 \u0648\u0645\u0646\u0627\u0639\u062a\u0647\u060c \u0648\u064a\u0633\u0627\u0639\u062f \u0641\u064a \u0627\u0644\u0625\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646.<\/p>\n

\u0641\u064a \u0627\u0644\u062e\u062a\u0627\u0645\u060c \u064a\u064f\u0646\u0635\u062d \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0645\u0646\u0627\u0642\u0634\u0629 \u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0623\u0643\u0644 \u062e\u0644\u0627\u0644 \u0634\u0647\u0631 \u0631\u0645\u0636\u0627\u0646 \u0627\u0644\u0645\u0628\u0627\u0631\u0643\u060c \u0648\u0623\u0641\u0636\u0644 \u0637\u0631\u0627\u0626\u0642 \u0623\u062e\u0630 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u062c\u0631\u0639\u0647\u0627 \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0645\u0639 \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0644\u0627\u0633\u064a\u0645\u0627 \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0635\u064a\u0627\u0645 \u0627\u0644\u062a\u064a \u062a\u062a\u0623\u062b\u0631 \u0641\u064a\u0647\u0627 \u062d\u0631\u0643\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0625\u0645\u062a\u0644\u0627\u0626\u0647\u0627\u060c \u0648\u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062d\u0627\u0635\u0644\u0629 \u0641\u064a \u062c\u0631\u064a\u0627\u0646 \u0627\u0644\u062f\u0645 \u0641\u064a \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0645\u0639 \u062a\u0623\u062b\u0631 \u062d\u0645\u0648\u0636\u0629 \u0645\u062d\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u0645\u0639\u062f\u0629.<\/p>\n

 <\/p>\n

\n

\n\u0627\u0644\u0645\u0635\u0627\u062f\u0631<\/span><\/p>\n

1- Ahmadpour S, Habibi MA, Hosseinimehr SJ. Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals. Curr Drug Metab. 2022;23(10):827-841. doi: 10.2174\/1389200223666220919121354. PMID: 36121082.<\/p>\n

2- de Gruil N, Pijl H, van der Burg SH, Kroep JR. Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity. Cancers (Basel). 2022 Mar 9;14(6):1390. doi: 10.3390\/cancers14061390. PMID: 35326541; PMCID: PMC8946179.<\/p>\n

3- Kikomeko J, Schutte T, van Velzen MJM, Seefat R, van Laarhoven HWM. Short-term fasting and fasting mimicking diets combined with chemotherapy: a narrative review. Ther Adv Med Oncol. 2023 Mar 22;15:17588359231161418. doi: 10.1177\/17588359231161418. PMID: 36970110; PMCID: PMC10037739.<\/p>\n

4- Lammers LA, Achterbergh R, van Schaik RHN, Romijn JA, Mathôt RAA. Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach. Clin Pharmacokinet. 2017 Oct;56(10):1231-1244. doi: 10.1007\/s40262-017-0515-7. PMID: 28229374; PMCID: PMC5591816.<\/p>\n

5- Lammers LA, Achterbergh R, Romijn JA, Mathôt RAA. Short-Term Fasting Alters Pharmacokinetics of Cytochrome P450 Probe Drugs: Does Protein Binding Play a Role? Eur J Drug Metab Pharmacokinet. 2018 Apr;43(2):251-257. doi: 10.1007\/s13318-017-0437-7. PMID: 28929443; PMCID: PMC5854751.<\/p>\n

6- Lammers LA, Achterbergh R, Mathôt RAA, Romijn JA. The effects of fasting on drug metabolism. Expert Opin Drug Metab Toxicol. 2020 Jan;16(1):79-85. doi: 10.1080\/17425255.2020.1706728. Epub 2019 Dec 24. PMID: 31851534.<\/p>\n

7- Moore RA, Derry S, Wiffen PJ, Straube S. Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs – a systematic review. Br J Clin Pharmacol. 2015 Sep;80(3):381-8. doi: 10.1111\/bcp.12628. Epub 2015 Jul 6. PMID: 25784216; PMCID: PMC4574824.<\/p>\n

8- Strait JE. Drug mimics beneficial effects of fasting in mice. 2022. https:\/\/medicine.wustl.edu\/news\/drug-mimics-beneficial-effects-of-fasting-in-mice\/ <\/a><\/p>\n

9- de Vries EM, Lammers LA, Achterbergh R, Klümpen HJ, Mathot RA, Boelen A, Romijn JA. Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. PLoS One. 2016 Jul 19;11(7):e0159552. doi: 10.1371\/journal.pone.0159552. PMID: 27434302; PMCID: PMC4951123.<\/p>\n

 <\/p>\n

\n\u062a\u0648\u0627\u0635\u0644 \u0645\u0639 \u0627\u0644\u0643\u0627\u062a\u0628: <\/span>fouadmohammad@yahoo.com\u200b<\/a><\/p>\n

 <\/p>\n

\u0627\u0644\u0622\u0631\u0627\u0621 \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u0627\u0644 \u0647\u064a \u0622\u0631\u0627\u0621 \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 \u0648\u0644\u064a\u0633\u062a\u060c \u0628\u0627\u0644\u0636\u0631\u0648\u0631\u0629\u060c \u0622\u0631\u0627\u0621 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0645\u062c\u062a\u0645\u0639 \u0627\u0644\u0639\u0644\u0645\u064a \u0627\u0644\u0639\u0631\u0628\u064a<\/span><\/span><\/p>\n

\n

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