{"id":15841,"date":"2020-10-28T01:25:41","date_gmt":"2020-10-28T01:25:41","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-1759\/"},"modified":"2020-10-28T01:25:41","modified_gmt":"2020-10-28T01:25:41","slug":"article-detail-1759","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-15841\/","title":{"rendered":"\u062a\u0635\u0646\u064a\u0641 \u0648\u062a\u0631\u0643\u064a\u0628 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0633\u062a\u062c\u062f (SARS-CoV-2) \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0645\u0631\u0636 \u0643\u0648\u0641\u064a\u062f-19 (COVID-19)"},"content":{"rendered":"

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\u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0648\u0627\u0644\u0630\u064a \u0644\u0627 \u064a\u0632\u0627\u0644 \u0628\u062f\u0631\u062c\u0627\u062a \u0645\u062a\u0641\u0627\u0648\u062a\u0629 \u0641\u064a \u0627\u0644\u0623\u0642\u0637\u0627\u0631 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u062e\u0627\u0635\u0629 \u0628\u0639\u062f \u0638\u0647\u0648\u0631 \u0627\u0644\u0645\u0648\u062c\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646\u0647 \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635. \u0648\u062a\u064f\u0639\u062a\u0628\u0631 \u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0646\u0634\u0648\u0621 \u0648\u0627\u0644\u062a\u0637\u0648\u0651\u064f\u0631 \"\"(phylogenetic analyses<\/span>) \u0623\u0641\u0636\u0644 \u0627\u0644\u0637\u0631\u0642 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0633\u0644\u0627\u0644\u0627\u062a \u0648\u0627\u0644\u0639\u0632\u0644\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u0623\u062d\u064a\u0627\u0621 \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0648\u0647\u0630\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u062a\u0648\u0636\u062d \u0627\u0644\u062a\u0642\u0627\u0631\u0628 \u0628\u064a\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u062d\u062a\u0649 \u0645\u0646 \u0646\u0641\u0633 \u0627\u0644\u0633\u0644\u0627\u0644\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0646\u0638\u0631\u064a\u0627\u062a \u062a\u0635\u0646\u064a\u0639 \u0647\u0630\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a\u060c \u0648\u062a\u0634\u0631\u062d \u0643\u064a\u0641\u064a\u0629 \u0627\u0646\u062a\u0642\u0627\u0644 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0645\u0646 \u0628\u0644\u062f \u0644\u0622\u062e\u0631 \u0648\u0645\u0646 \u0642\u0627\u0631\u0629 \u0625\u0644\u0649 \u0623\u062e\u0631\u0649\u060c \u0648\u0644\u0643\u0646\u0646\u0627 \u0646\u0631\u0649 \u0623\u0646\u0647 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u0644\u064a\u0633 \u0647\u0646\u0627\u0643 \u062f\u0631\u0627\u0633\u0627\u062a \u0646\u0647\u0627\u0626\u064a\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u064a\u064f\u062c\u0645\u0650\u0639\u064f \u0639\u0644\u064a\u0647\u0627 \u0627\u0644\u0639\u0644\u0645\u0627\u0621.<\/p>\n

\u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062e\u0627\u0631\u062c\u064a \u0644\u0644\u0641\u064a\u0631\u0648\u0633 <\/span><\/p>\n

\u0643\u0645\u0627 \u0647\u064a \u0627\u0644\u062d\u0627\u0644 \u0645\u0639 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0651\u0629\u060c \u0641\u0627\u0644\u062d\u064f\u0628\u064e\u064a\u0652\u0628\u064e\u0629 \u0623\u0648 \u0627\u0644\u062c\u064f\u0633\u064e\u064a\u0652\u0645\u064e\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 (virus particle<\/span>) \u062f\u0627\u0626\u0631\u064a\u0629 \u0627\u0644\u0634\u0643\u0644 \u0628\u0645\u0642\u064a\u0627\u0633 \u0645\u0646 80 \u0625\u0644\u0649 \"\"160 \u0646\u0627\u0646\u0648\u0645\u062a\u0631\u060c \u062a\u062d\u062a\u0648\u064a \u0641\u064a \u0648\u0633\u064e\u0637\u0650\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 (\u0627\u0644\u062c\u064a\u0646\u0648\u0645) \u0648\u0647\u064a \u062d\u0645\u0636 \u0646\u0648\u0648\u064a \u0631\u0627\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0649 (\u0631\u0646\u0627 RNA<\/span>) \u064a\u062a\u0648\u0627\u062c\u062f \u0628\u0634\u0643\u0644 \u062d\u0644\u0632\u0648\u0646\u064a (helical<\/span>)\u060c \u0648\u064a\u064f\u063a\u0644\u0651\u0641 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u062d\u0645\u0627\u064a\u062a\u0647 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0633\u0645\u064a (\u0646 N<\/span>)\u060c \u0648\u0643\u0644\u0627\u0647\u0645\u0627 \u064a\u0643\u0648\u0646\u0627\u0646 \u0627\u0644\u063a\u0637\u0627\u0621 \u0627\u0644\u0646\u0648\u0648\u064a \u0623\u0648 \u0627\u0644\u0645\u0631\u0643\u0632\u064a (nucleocapsid<\/span>) \u0627\u0644\u0630\u064a \u064a\u0642\u0639 \u0641\u064a \u0648\u0633\u0637 \u0627\u0644\u062d\u0628\u064a\u0628\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629\u060c \u0648\u064a\u063a\u0637\u064a \u0627\u0644\u063a\u0637\u0627\u0621 \u0627\u0644\u0646\u0648\u0648\u064a \u063a\u0634\u0627\u0621 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0637\u0628\u0642\u0629 \u0645\u0646 \u0627\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u063a\u0627\u0644\u0628\u064a\u062a\u0647 \u0645\u064f\u0634\u062a\u0642\u0651\u064c \u0645\u0646 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0644\u0648\u064a \u0644\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u0648\u0628\u0648\u0621\u0629\u060c \u0648\u064a\u062f\u062e\u0644 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u063a\u0634\u0627\u0621 \u0623\u0631\u0628\u0639\u0629 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062a\u0628\u0631\u0632 \u0625\u0644\u0649 \u062e\u0627\u0631\u062c \u0627\u0644\u063a\u0634\u0627\u0621 \u0628\u0645\u0633\u0627\u0641\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u0623\u0647\u0645\u0647\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0637\u062d\u064a \u0627\u0644\u0628\u0627\u0631\u0632 (\u0633 S<\/span>)\u060c \u062b\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u063a\u0644\u0627\u0641 (\u0645 M<\/span>)\u060c \u062b\u0645 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0635\u063a\u064a\u0631 \u0644\u0644\u063a\u0644\u0627\u0641 (\u0625\u064a E<\/span>)\u060c \u062b\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u064a\u0632 \u0627\u0644\u0645\u064f\u062e\u064e\u062b\u0651\u0650\u0631 (\u0625\u062a\u0634 \u0625\u064a HE<\/span>)\u060c \u0648\u0643\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645\u0651\u064e \u0630\u0650\u0643\u0631\u0647\u0627 \u0647\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u0629 (structural<\/span>) \u0627\u0644\u062a\u064a \u062a\u064f\u0643\u0648\u0651\u0650\u0646 \u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062d\u0628\u064a\u0628\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0627 \u064a\u064f\u0645\u0643\u0646 \u0631\u0624\u064a\u062a\u0647\u0627 \u0625\u0644\u0627 \u0628\u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0628\u0635\u0628\u063a\u0629 \u0633\u0627\u0644\u0628\u0629 \u0623\u0648 \u0628\u0635\u0628\u063a\u0629 \u0645\u064f\u0644\u0648\u0651\u0646\u064e\u0629\u060c \u0648\u064a\u0628\u064a\u0651\u0646 \u0627\u0644\u0634\u0643\u0644 \u0631\u0642\u0645 3 \u0631\u0633\u0645\u0627\u064b \u062a\u062e\u0637\u064a\u0637\u064a\u0627 \u0644\u0644\u062d\u0628\u064a\u0628\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 \u0645\u062d\u062a\u0648\u064a\u0629\u064b \u0643\u0644 \u0647\u0630\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u0629.<\/p>\n

\u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0644\u0641\u064a\u0631\u0648\u0633 <\/span><\/p>\n

\u064a\u062a\u0643\u0648\u0646 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u0647\u0630\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u0627\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0649 (\u0631\u0646\u0627 RNA<\/span>)\u060c \u0623\u062d\u0627\u062f\u064a \u0627\u0644\u0646\u0633\u064a\u0644\u0629 (single stranded<\/span>) \u0628\u062a\u0643\u0648\u064a\u0646 \"\"\u0625\u064a\u062c\u0627\u0628\u064a (positive configuration<\/span>)\u060c \u0623\u064a \u0623\u0646 \u0628\u0625\u0645\u0643\u0627\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0623\u0646 \u064a\u0646\u0633\u062e \u0646\u0641\u0633\u0647 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u064a\u0629 \u0628\u0639\u062f \u062f\u062e\u0648\u0644\u0647 \u0625\u0644\u064a\u0647\u0627 \u0628\u062f\u0648\u0646 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0645\u0639\u0647 \u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0646\u0633\u062e\u060c \u0648\u064a\u062a\u0648\u0627\u062c\u062f \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0628\u062a\u0633\u0644\u0633\u0644 \u062d\u0648\u0627\u0644\u064a \u062b\u0644\u0627\u062b\u0648\u0646 \u0623\u0644\u0641\u0627 \u0645\u0646 \u0627\u0644\u0648\u062d\u062f\u0627\u062a \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u064a\u0651\u0629 (30 kb<\/span>)\u060c \u0648\u0642\u062f \u0643\u0627\u0646 \u0647\u0630\u0627 \u0623\u0648\u0651\u0644 \u062a\u0633\u0644\u0633\u0644 \u064a\u064f\u0646\u0634\u0631 \u0645\u0646 \u0639\u064f\u0632\u0644\u0627\u062a\u064d \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u064f\u062e\u0630\u062a \u0645\u0646 \u0623\u0648\u0627\u0626\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0645\u062f\u064a\u0646\u0629 \u0648\u0648\u0647\u0627\u0646 \u0628\u0627\u0644\u0635\u064a\u0646 (7). \u0648\u0643\u0628\u0627\u0642\u064a \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0641\u0625\u0646 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u0641\u062a\u0648\u062d (Open Reading Frame – ORF<\/span>) \u0644\u0646\u0633\u062e \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0645\u062a\u063a\u064a\u0631 \u062c\u062f\u0627\u060c \u0641\u0623\u0648\u0644\u0647\u0627 \u0645\u0646 \u062c\u0647\u0629 \u0627\u062a\u0651\u062c\u0627\u0647 \u0627\u0644\u0646\u0633\u062e (5’<\/span> ) \u0647\u0648 ORF1a\/b<\/span> \u0627\u0644\u0630\u064a \u064a\u064f\u0643\u0648\u0651\u0650\u0646 \u062a\u0642\u0631\u064a\u0628\u0627 \u062b\u064f\u0644\u062b\u064a \u0637\u0648\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u0627\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0649 \u0644\u0647\u0630\u0627 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\u060c \u062b\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u063a\u0644\u0627\u0641 (\u0645 M<\/span>) \u060c \u062b\u0645 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0635\u063a\u064a\u0631 \u0644\u0644\u063a\u0644\u0627\u0641 (\u0625\u064a E<\/span>) \u060c \u062b\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0625\u0633\u062a\u0631\u064a\u0632 \u0627\u0644\u0645\u064f\u062e\u064e\u062b\u0651\u0650\u0631 (\u0625\u062a\u0634 \u0625\u064a HE<\/span>) \u060c \u0648\u064a\u062a\u0628\u064a\u0651\u064e\u0646 \u0623\u0635\u0648\u0644 \u0647\u0630\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u064a\u0646\u064a \u0641\u064a \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062a\u062e\u0637\u064a\u0637\u064a \u0631\u0642\u0645 4.<\/p>\n

\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0637\u062d\u064a \u0627\u0644\u0628\u0627\u0631\u0632 "\u0633" \u0623\u0648 "S<\/span>"<\/span><\/p>\n

\u0644\u0639\u0644\u0651 \u0623\u0647\u0645 \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u0647\u0630\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0647\u0648 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0637\u062d\u064a \u0627\u0644\u0628\u0627\u0631\u0632 \u0648\u0627\u0644\u0630\u064a \u064a\u0631\u062a\u0628\u0637 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u063a\u0632\u0648 \"\"\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0648\u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0627\u0633\u0645 \u0625\u064a\u06332 (ACE2<\/span>)\u060c \u0648\u0647\u0630\u0627 \u0627\u062e\u062a\u0635\u0627\u0631 \u0644\u0645\u0633\u0645\u0649 (Angiotensin-Converting Enzyme 2<\/span>) \u0625\u0646\u0632\u064a\u0645 \u062a\u062d\u0648\u064a\u0644 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\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0647\u0648 \u0645\u0627 \u064a\u062a\u0645 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u064a\u0647 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u064f\u062a\u064e\u0648\u064e\u0642\u0651\u064e\u0639\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0642\u0631\u064a\u0628.<\/p>\n

\u0627\u0644\u062e\u0627\u062a\u0645\u0629<\/span><\/p>\n

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\n\u0627\u0644\u0645\u0631\u0627\u062c\u0639<\/span><\/p>\n

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