{"id":15717,"date":"2020-04-10T19:57:15","date_gmt":"2020-04-10T19:57:15","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-1593\/"},"modified":"2020-04-10T19:57:15","modified_gmt":"2020-04-10T19:57:15","slug":"article-detail-1593","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-15717\/","title":{"rendered":"\u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0627\u0644\u0645\u062e\u0644\u0642\u0629 \u0643\u0639\u0644\u0627\u062c \u0645\u062d\u062a\u0645\u0644 \u0644\u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627"},"content":{"rendered":"

\u064a\u062a\u0643\u0648\u0646 \u062c\u0633\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0623\u064a\u0627\u064b \u0643\u0627\u0646 \u0646\u0648\u0639\u0647\u0627 \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0648\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062d\u0627\u0645\u0636 \u0646\u0648\u0648\u064a Nucleic Acid<\/span> \u0648\u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0630\u064a \u064a\u062d\u064a\u0637 \u0628\u0647 \u0648\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 Protein Envelope<\/span>. \u0648\u064a\u0634\u0628\u0647 \u0627\u0644\u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a (DNA<\/span>) \u0644\u062c\u0633\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0630\u0644\u0643 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u062d\u064a\u0629 \u0648\u0644\u0643\u0646 \u0623\u0635\u063a\u0631 \u0641\u064a \u0627\u0644\u0637\u0648\u0644 \u0643\u062b\u064a\u0631\u0627\u064b\u060c \u0648\u0627\u0644\u0637\u0648\u0644 \u0647\u0646\u0627 \u0645\u0639\u0646\u0627\u0647 \u0639\u062f\u062f \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629.<\/span><\/p>\n

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\n"\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a" <\/strong>Poly(I:C)<\/span><\/strong><\/span><\/p>\n

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\u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629\u060c \u062e\u0627\u0635\u0629 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u0645 \u0628\u0642\u062a\u0644 \u0627\u0644\u0648\u0631\u0645.<\/p>\n

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\u0648\u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u062a\u0648\u0635\u0644\u062a \u0644\u0641\u0643\u0631\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u0645\u0627\u0645\u0627 \u062d\u064a\u0646\u0626\u0630\u060c \u0648\u0647\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0627\u062f\u0629 "\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a" \u0644\u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u064a \u0646\u0639\u0627\u0644\u062c \u0628\u0647\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u062d\u0642\u0646 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645\u064a\u0629 . \u0648\u0628\u0627\u0644\u0637\u0628\u0639 \u0627\u062e\u062a\u064a\u0627\u0631\u064a \u0644\u0645 \u064a\u0643\u0646 \u0648\u0644\u064a\u062f \u0627\u0644\u0635\u062f\u0641\u0629 \u0628\u0644 \u0646\u062a\u064a\u062c\u0629 \u0628\u062d\u062b \u0645\u0633\u062a\u0641\u064a\u0636 \u0639\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u062e\u0635\u0627\u0626\u0635 \u0645\u062d\u062f\u062f\u0629 \u0644\u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 Stimulants of Innate Immune Cells<\/span> \u0648\u0630\u0644\u0643 \u0644\u062a\u062d\u0642\u064a\u0642 \u0641\u0631\u0636\u064a\u0629 \u0623\u0646 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 Non Specific (Innate) Immune Cells<\/span> \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0646\u0634\u0627\u0637 \u0648\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 Specific (Adaptive) Immune Cells<\/span> \u0636\u062f \u0627\u0644\u0648\u0631\u0645. \u0648\u0647\u0630\u0627 \u0645\u0627 \u062a\u0648\u0642\u0639\u062a\u0647 \u0644\u0645\u0627\u062f\u0629 "\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a" PolyI(I:C)<\/span> \u0639\u0646\u062f\u0645\u0627 \u062a\u0645 \u062a\u062c\u0631\u064a\u0628\u0647\u0627 \u0648\u0623\u0639\u0637\u062a \u0646\u062a\u0627\u0626\u062c \u0631\u0627\u0626\u0639\u0629 \u0623\u0628\u0647\u0631\u062a \u0627\u0644\u0641\u0631\u064a\u0642 \u0627\u0644\u0628\u062d\u062b\u064a. \u0648\u0647\u0646\u0627 \u0643\u0627\u0646\u062a \u0628\u062f\u0627\u064a\u0629 \u0642\u0635\u062a\u064a \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0645\u0639 \u0647\u0630\u0647 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0645\u062d\u0641\u0632\u0629 \u0644\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u062a\u064a \u0646\u0634\u0631\u062a \u0639\u0644\u064a\u0647\u0627 \u0623\u0643\u062b\u0631 \u0645\u0646 15<\/span> \u0628\u062d\u062b\u0627\u064b (\u0623\u0646\u0638\u0631 \u0627\u0644\u0645\u0631\u0627\u062c\u0639) \u0641\u064a \u062f\u0648\u0631\u064a\u0627\u062a \u0639\u0644\u0645\u064a\u0629 \u062f\u0648\u0644\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u062a\u062e\u0635\u0635 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u062d\u062a\u0649 \u0648\u0635\u0644\u062a \u0625\u0644\u0649 \u062a\u062c\u0631\u0628\u062a\u0647\u0627 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 Pancreatic Cancer<\/span>. (\u0623\u0646\u0638\u0631 \u0627\u0644\u0645\u0631\u0627\u062c\u0639)<\/p>\n

\n\u0645\u0627 \u0647\u0648<\/strong>" <\/span><\/strong>\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a"<\/strong><\/span><\/p>\n

\"\""\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a" PolyI(I:C)<\/span> \u0647\u0648 \u0645\u0627\u062f\u0629 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0645\u064f\u062e\u0644\u0651\u0642\u0629 \u0645\u0646 \u062d\u0645\u0636 \u0646\u0648\u0648\u064a \u0631\u064a\u0628\u0648\u0632\u064a (Synthetic RNA) <\/span>\u0639\u0628\u0627\u0631\u0647 \u0639\u0646 \u0628\u0648\u0644\u064a\u0645\u0631 \u0645\u0646 \u0627\u0644\u0646\u064a\u0648\u0643\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u062e\u0644\u0642\u0629Synthetic Nucleotides <\/span>. \u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u0639\u0644\u0645\u064a \u0644\u0647 \u0647\u0648:  Polyinosinic:polycytidylic acid<\/span>. \u0648\u0647\u0630\u0627 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u064f\u062e\u0644\u0651\u0642 \u0644\u0647 \u0642\u062f\u0631\u0629 \u0639\u0627\u0644\u064a\u0629 \u0639\u0644\u0649 \u062f\u062e\u0648\u0644 \u0623\u064a \u062e\u0644\u064a\u0629 \u062a\u062d\u0645\u0644 \u0639\u0644\u0649 \u0633\u0637\u062d\u0647\u0627 \u0645\u0633\u062a\u0642\u0628\u0644 \u0628\u0631\u0648\u062a\u064a\u0646\u064a \u064a\u062f\u0639\u064a TLR3 <\/span> \u0648\u0628\u0631\u0648\u062a\u064a\u0646 RKR <\/span>\u0627\u0644\u0645\u0648\u062c\u0648\u062f \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u064a\u0629 \u0641\u064a \u0627\u0644\u0633\u064a\u062a\u0648\u0628\u0644\u0627\u0632\u0645.<\/p>\n

\u0648\u0645\u0633\u062a\u0642\u0628\u0644  TLR3<\/span> \u0647\u0648 \u0648\u0627\u062d\u062f \u0645\u0646 \u062b\u0644\u0627\u062b\u0629 \u0639\u0634\u0631 \u0646\u0648\u0639\u0627 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u064a\u0629  \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629  \u0628\u0643\u062b\u0631\u0629  \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u063a\u064a\u0631 \u0645\u062a\u062e\u0635\u0635\u0629 \u0648\u0643\u0630\u0644\u0643 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u0648\u0644\u0643\u0646 \u0628\u062f\u0631\u062c\u0629 \u0623\u0642\u0644 .<\/span>\u0648\u062a\u0633\u0645\u0649 \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a  Toll-like receptors (TLRs)<\/span> \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647\u0627 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629  \u0641\u064a \u062d\u0634\u0631\u0629 \u0630\u0628\u0627\u0628\u0629 \u0627\u0644\u0641\u0627\u0643\u0647\u0629  Drosophila<\/span> \u0648\u0648\u062c\u062f \u0623\u0646 \u0644\u0647\u0627 \u062f\u0648\u0631 \u0643\u0628\u064a\u0631  \u0641\u064a  \u0642\u062f\u0631\u0629 \u0627\u0644\u062d\u0634\u0631\u0629  \u0639\u0644\u0649 \u0625\u062f\u0631\u0627\u0643 \u0633\u0637\u062d\u0647\u0627 \u0627\u0644\u0638\u0627\u0647\u0631\u064a surface<\/span>   Dorsal<\/span>\u0645\u0646 \u0627\u0644\u0628\u0627\u0637\u0646\u064a surface<\/span>  Ventral<\/span> \u0648\u0643\u0630\u0644\u0643  \u0641\u064a \u0627\u0644\u062d\u0645\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0639\u062f\u0648\u0649 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0629  \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 .<\/span><\/p>\n

\u0648\u0628\u062f\u0631\u0627\u0633\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a  TLRs<\/span>\u0641\u064a \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0648\u0643\u0630\u0644\u0643 \u0627\u0644\u0625\u0646\u0633\u0627\u0646\u060c \u0648\u062c\u062f \u0623\u0646\u0647\u0627  \u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0643\u0627\u0626\u0646\u0627\u062a \u0627\u0644\u062d\u064a\u0629 \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0646\u0628\u0627\u062a  \u0643\u0648\u0633\u064a\u0644\u0629 \u063a\u0631\u064a\u0632\u064a\u0629  \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a\u060c  \u062d\u064a\u062b \u0623\u0646\u0647\u0627 \u062a\u0639\u0645\u0644 \u0643\u0642\u0631\u0648\u0646 \u0627\u0633\u062a\u0634\u0639\u0627\u0631 \u0644\u0644\u062e\u0637\u0631 \u0627\u0644\u0643\u0627\u0645\u0646 \u0641\u064a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628 \u0646\u0641\u0633\u0647 \u0623\u0648 \u0623\u062d\u062f \u0645\u0646\u062a\u062c\u0627\u062a\u0647  \u0627\u0644\u0636\u0627\u0631\u0629 .<\/span> \u0648\u0648\u062c\u062f \u0623\u0646 \u0643\u0644 \u0645\u0633\u062a\u0642\u0628\u0644 \u0645\u0646 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0639\u0634\u0631 \u0645\u0646  TLRs<\/span>\u064a\u0642\u0648\u0645 \u0628\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0645\u064a\u0643\u0631\u0648\u0628 \u0645\u062d\u062f\u062f. \u0641\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u064a\u0642\u0648\u0645  TLR3<\/span> \u0628\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a  \u0627\u0644\u062a\u064a \u064a\u062a\u0643\u0648\u0646 \u062c\u0633\u0645\u0647\u0627 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0632\u062f\u0648\u062c  Double-Stranded RNA (dsRNA)<\/span> \u0623\u0648 \u0645\u0646\u062a\u062c\u0627\u062a\u0647 \u0623\u062b\u0646\u0627\u0621 \u063a\u0632\u0648\u0647 \u0644\u0644\u062e\u0644\u064a\u0629 \u0623\u0648 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u062e\u0644\u0651\u0642\u0629  \u0627\u0644\u0645\u0634\u0627\u0628\u0647\u0629  \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0628 \u0645\u062b\u0644 "\u0628\u0648\u0644\u064a \u0627\u064a \u0633\u064a" Poly(I:C)<\/span>. \u0628\u064a\u0645\u0646\u0627 \u064a\u0642\u0648\u0645 \u0645\u0633\u062a\u0642\u0628\u0644  TLR7<\/span> \u0628\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a  \u0627\u0644\u062a\u064a \u064a\u062a\u0643\u0648\u0646 \u062c\u0633\u0645\u0647\u0627 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0646\u0641\u0631\u062fSingle-Stranded RNA (sRNA)<\/span>. \u0648\u064a\u0642\u0648\u0645  TLR9<\/span> \u0628\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a  \u0627\u0644\u062a\u064a \u064a\u062a\u0643\u0648\u0646 \u062c\u0633\u0645\u0647\u0627 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062f\u064a\u0648 \u0627\u0648\u0643\u0633\u064a \u0631\u064a\u0628\u0648\u0632\u064a (DNA<\/span>) \u0648\u0643\u0630\u0644\u0643 DNA<\/span> \u0644\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u063a\u0646\u064a \u0628\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0645\u064a\u062b\u064a\u0644 Methyl Group (CH3)<\/span> \u062f\u0648\u0646 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 DNA<\/span> \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629  \u0627\u0644\u0641\u0642\u064a\u0631 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a .<\/span>\u0648\u064a\u0642\u0648\u0645  TLR4<\/span> \u0628\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627  \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0633\u0627\u0644\u0628  Gram Negative Bacteria<\/span> (\u0623\u064a \u0627\u0644\u062a\u064a \u0644\u0627 \u062a\u0635\u0628\u063a \u0628\u0635\u0628\u063a\u0629 \u062c\u0631\u0627\u0645) \u0648\u0627\u0644\u062a\u064a \u062a\u0639\u064a\u0634 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u064a\u0629 \u0623\u0648 \u0645\u0646\u062a\u062c\u0627\u062a\u0647\u0627 \u0627\u0644\u0633\u0627\u0645\u0629 \u0648\u0623\u0647\u0645\u0647\u0627  \u0645\u0627\u062f\u0629Lipopolysacharide (LPS) <\/span>. \u0623\u0645\u0627 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u0645\u0648\u062c\u0628\u0629  \u0627\u0644\u0635\u0628\u063a\u0629Gram Negative Bacteria<\/span> (\u0623\u064a \u0627\u0644\u062a\u064a \u062a\u0635\u0628\u063a \u0628\u0635\u0628\u063a\u0629 \u062c\u0631\u0627\u0645) \u0648\u0627\u0644\u062a\u064a \u062a\u0639\u064a\u0634 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a\u0642\u0648\u0645 \u0645\u0633\u062a\u0642\u0628\u0644  TLR2\/6 <\/span>\u0628\u062a\u0639\u0631\u0641 \u0639\u0644\u064a\u0647\u0627 \u0648\u0643\u0630\u0644\u0643 \u0645\u0646\u062a\u062c\u0627\u062a\u0647\u0627.<\/span><\/p>\n

\"\"\u0648\u0627\u0644\u0639\u062c\u064a\u0628 \u0623\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a TLRs <\/span>\u0627\u0644\u062a\u064a \u062a\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 (TLR3, TLR7 and TLR9) <\/span>\u0623\u064a\u0627\u064b \u0643\u0627\u0646 \u0646\u0648\u0639\u0647\u0627 \u062a\u0648\u062c\u062f \u0641\u064a \u0627\u0644\u0633\u064a\u062a\u0648\u0628\u0644\u0627\u0632\u0645 \u0648\u0644\u064a\u0633 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u064a\u0629 \u0648\u0630\u0644\u0643 \u0644\u0623\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0647\u064a \u0645\u0646\u062a\u062c\u0627\u062a \u0641\u064a\u0631\u0648\u0633\u064a\u0629 \u0623\u0648 \u0628\u0643\u062a\u064a\u0631\u064a\u0629 \u062a\u063a\u0632\u0648 \u0627\u0644\u062e\u0644\u064a\u0629 \u0648\u062a\u0639\u064a\u0634 \u0641\u064a \u0627\u0644\u0633\u064a\u062a\u0648\u0628\u0644\u0627\u0632\u0645 .<\/span>\u0648\u0642\u062f \u0623\u062f\u0649 \u0627\u0643\u062a\u0634\u0627\u0641TLRs <\/span> \u0641\u064a \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0641\u064a \u0628\u062f\u0627\u064a\u0629  2000 <\/span>\u0625\u0644\u0649 \u0625\u062d\u062f\u0627\u062b \u062b\u0648\u0631\u0629 \u0639\u0644\u0645\u064a\u0629 \u0641\u064a \u0622\u0644\u064a\u0629 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u062e\u0627\u0635\u0629 \u063a\u064a\u0631  \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0645\u062b\u0644 \u062e\u0637 \u0627\u0644\u062f\u0641\u0627\u0639 \u0627\u0644\u0623\u0648\u0644 \u0627\u0644\u0630\u064a \u064a\u062a\u0639\u0627\u0645\u0644 \u0645\u0639 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0648\u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646\u0647\u0627 \u0628\u0633\u0644\u0627\u0645.<\/p>\n

\u0648\u0643\u0627\u0646 \u0645\u0646 \u062d\u0633\u0646 \u062d\u0638\u064a \u0627\u0644\u0639\u0644\u0645\u064a \u0623\u0646 \u0627\u0643\u062a\u0634\u0627\u0641 TLRs <\/span> \u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u062a\u0637\u0628\u064a\u0642 \u0641\u0643\u0631\u062a\u064a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0627\u062f\u0629 "\u0627\u0644\u0628\u0648\u0644\u064a  \u0623\u064a \u0633\u064a"<\/span> \u062d\u064a\u062b \u0627\u062b\u0628\u062a\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0622\u062e\u0631\u064a\u0646 \u0644\u0627\u062d\u0642\u0627\u064b \u0623\u0646\u0647\u0627 \u062a\u0631\u062a\u0628\u0637 \u0628\u0645\u0633\u062a\u0642\u0628\u0644 TLR3<\/span> \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629\u060c \u0645\u0645\u0627 \u0623\u0639\u0637\u0649 \u0644\u0641\u0643\u0631\u062a\u064a \u0628\u0639\u062f\u0627\u064b \u062c\u062f\u064a\u062f\u0627\u064b \u0644\u0645 \u0623\u0641\u0643\u0631 \u0641\u064a\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0639\u0646 \u0643\u064a\u0641\u064a\u0629 \u062a\u0623\u062b\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0645\u0627\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629. \u0641\u0639\u0646\u062f \u0627\u0631\u062a\u0628\u0627\u0637 \u062d\u0645\u0636 "\u0628\u0648\u0644\u064a \u0627\u064a \u0633\u064a" \u0628\u0645\u0633\u062a\u0642\u0628\u0644 TLR3<\/span>\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u064a\u0629 \u062a\u0643\u0648\u0646 \u0646\u0647\u0627\u064a\u062a\u0647\u0627 \u062a\u0646\u0634\u064a\u0637 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0623\u0647\u0645\u0647\u0627  NF-K(kappa)B<\/span> \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0648\u0627\u0644\u0630\u064a \u064a\u0624\u062f\u064a \u0628\u062f\u0648\u0631\u0647 \u0625\u0644\u0649 \u062a\u062e\u0644\u064a\u0642 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0648\u0623\u0647\u0645\u0647\u0627 \u0627\u0644\u0627\u0646\u062a\u064a\u0631\u0641\u0631\u0648\u0646  \u0628\u0623\u0646\u0648\u0627\u0639\u0647 \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u0645\u0644 \u0639\u0644\u0649 \u062a\u0646\u0634\u064a\u0637  \u0633\u0631\u064a\u0639 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629  \u0641\u064a  \u0627\u0644\u062f\u0645 \u0648\u0627\u0644\u0637\u062d\u0627\u0644 \u0648\u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629  \u0648\u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0631\u0626\u0629 \u0641\u064a\u062c\u0639\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0643\u0644\u0647 \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0633\u062a\u0646\u0641\u0627\u0631\u064d \u0639\u0627\u0645\u064d.<\/p>\n

\u0648\u064a\u0643\u0645\u0646 \u0627\u0644\u0633\u0631 \u0641\u064a \u0642\u062f\u0631\u0629 \u0645\u0631\u0643\u0628 "\u0628\u0648\u0644\u064a \u0627\u064a \u0633\u064a" \u0639\u0644\u0649 \u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0641\u064a \u0643\u0648\u0646\u0647 \u064a\u0634\u0628\u0647 \u0628\u0646\u0633\u0628\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u062a\u0631\u0643\u064a\u0628\u0647 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0632\u062f\u0648\u062c  Double Stranded RNA (dsRNA)<\/span> \u0627\u0644\u062e\u0627\u0635 \u0628\u0645\u0639\u0638\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0648\u0627\u0644\u0630\u064a \u064a\u062a\u0643\u0648\u0646 \u0623\u062b\u0646\u0627\u0621 \u063a\u0632\u0648 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0644\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u062d\u064a\u0629. \u0648\u0628\u0645\u0639\u0646\u0649 \u0622\u062e\u0631 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0643\u0628 \u0639\u0646\u062f \u062d\u0642\u0646\u0647 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u064a\u0634\u0628\u0647 \u0627\u0644\u0639\u062f\u0648\u0649 \u0628\u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0648\u0644\u0643\u0646 \u062f\u0648\u0646 \u0625\u0635\u0627\u0628\u0629 \u062d\u0642\u064a\u0642\u064a\u0629 \u0648\u0644\u0630\u0644\u0643 \u0641\u062d\u0642\u0646\u0647 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0627\u0646\u062a\u064a\u0631\u0641\u064a\u0631\u0648\u0646 Interferons<\/span> \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u0645\u062d\u0641\u0632\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629. \u0648\u0643\u0627\u0646\u062a \u0647\u0630\u0647 \u0627\u0644\u062e\u0648\u0627\u0635 \u0647\u064a \u0627\u0644\u0633\u0628\u0628 \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0643\u0639\u0627\u0645\u0644 \u0645\u062d\u0641\u0632 \u0648\u0645\u0646\u0634\u0637 \u0642\u0648\u064a    Immunostimulan<\/span>\u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f. \u0648\u0647\u0630\u0627 \u0645\u0627 \u062d\u062f\u062b \u0628\u0627\u0644\u0641\u0639\u0644\u060c \u062d\u064a\u062b \u0648\u062c\u062f\u0646\u0627 \u062a\u0623\u062b\u064a\u0631 \u0645\u0646\u0634\u0637 \u0642\u0648\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0628\u062f\u0631\u062c\u0629 \u0643\u0628\u064a\u0631\u0629 \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0642\u062a\u0644 \u0627\u0644\u0648\u0631\u0645 \u0628\u0637\u0631\u064a\u0642\u0629 \u063a\u064a\u0631 \u0645\u062a\u062e\u0635\u0635\u0629  Cytotoxic Natural Killer (NK) cells <\/span> \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0642\u062f\u0645 \u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u062c\u0633\u0645 \u0627\u0644\u0648\u0631\u0645  Antigen Presenting Cells<\/span> \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0642\u0627\u062a\u0644\u0629 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0645\u062a\u062e\u0635\u0635 Cytotoxic CD8+ T cells<\/span>. \u0648\u0648\u062c\u062f\u0646\u0627 \u0623\u0646 \u0627\u0644\u0633\u0628\u0628 \u0648\u0631\u0627\u0621 \u0647\u0630\u0627 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u0646\u0634\u0637 \u0647\u0648 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0627\u0646\u062a\u064a\u0631\u0641\u064a\u0631\u0648\u0646 \u0628\u0623\u0646\u0648\u0627\u0639\u0647 \u0648\u0623\u0643\u062b\u0631 \u0645\u0646 \u0639\u0634\u0631\u0629 \u0623\u0646\u0648\u0627\u0639 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0627\u0646\u062a\u064a\u0631\u0641\u064a\u0631\u0648\u0646 (IFNα, IFNβ, IFNg)<\/span> \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0623\u0647\u0645\u064a\u062a\u0647 \u0641\u064a \u0627\u0644\u0642\u0636\u0627\u0621 \u0639\u0644\u0649 \u0627\u0644\u0648\u0631\u0645 \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a IL1,IL12, TNFα, MCP1, CCL2, CCL3<\/span>. \u0648\u0648\u062c\u062f\u0646\u0627 \u0623\u064a\u0636\u0627 \u0623\u0646 \u0625\u0641\u0631\u0627\u0632 \u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u062f \u064a\u062a\u0645 \u0633\u0631\u064a\u0639\u0627 \u0648\u0641\u064a \u0623\u0648\u0642\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0648\u0628\u0622\u0644\u064a\u0629 \u0645\u062d\u062f\u062f\u0629. \u0648\u0628\u0627\u0644\u0637\u0628\u0639\u060c \u0642\u0645\u0646\u0627 \u0628\u0646\u0634\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u062f\u0648\u0631\u064a\u0627\u062a \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0627\u0644\u0645\u0647\u0645\u0629 \u0648\u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645. \u0648\u0642\u062f \u0627\u0634\u062a\u0631\u0643 \u0641\u064a \u0625\u062c\u0631\u0627\u0621 \u0647\u0630\u0647 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0646\u062e\u0628\u0629 \u0645\u062a\u0645\u064a\u0632\u0629 \u0645\u0646 \u0637\u0644\u0627\u0628\u064a \u0648\u0632\u0645\u0644\u0627\u0626\u064a \u0628\u0627\u0644\u062c\u0627\u0645\u0639\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0628\u0643\u0627\u0631\u0648\u0644\u064a\u0646\u0627 \u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0629 \u0628\u0623\u0645\u064a\u0631\u0643\u0627 \u0648\u0645\u0635\u0631. <\/span>\u0648\u0642\u062f \u062a\u0645 \u0646\u0634\u0631 \u0641\u0635\u0644 \u0641\u064a \u0643\u062a\u0627\u0628 \u0639\u0646  \u062a\u0623\u062b\u064a\u0631 "\u0627\u0644\u0628\u0648\u0644\u064a \u0623\u064a \u0633\u064a"  \u0627\u0644\u0645\u062d\u0641\u0632  \u0644\u0644\u0645\u0646\u0627\u0639\u0629. (\u0627\u0646\u0638\u0631 \u0627\u0644\u0645\u0631\u0627\u062c\u0639).<\/p>\n

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