{"id":15666,"date":"2019-12-29T13:01:12","date_gmt":"2019-12-29T13:01:12","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-1522\/"},"modified":"2019-12-29T13:01:12","modified_gmt":"2019-12-29T13:01:12","slug":"article-detail-1522","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-15666\/","title":{"rendered":"\u0647\u0644 \u0639\u0634\u0645\u0627\u0648\u064a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0639\u0644\u0627\u0645\u0629 \u0639\u0644\u0649 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631\u061f!"},"content":{"rendered":"<p dir=\"RTL\" style=\"text-align: justify;\"><span style=\"color:#008080;\"><span dir=\"LTR\">&quot;<\/span>\u0648\u0643\u0645\u0627 \u064a\u062d\u0643\u0645 \u0627\u0644\u0642\u0627\u0636\u064a \u0628\u0627\u0644\u0625\u0639\u062f\u0627\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u062a\u0647\u0645 \u0648\u064a\u0646\u0641\u0630\u0647 \u0639\u0634\u0645\u0627\u0648\u064a\u060c 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\u0627\u0644\u0645\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0648\u0631\u0627\u0621 \u0642\u0648\u0629 \u062a\u062d\u0645\u064a\u0647\u0645 \u0628\u0639\u062f \u0639\u0645\u0631 \u0627\u0644\u0645\u0627\u0626\u0629<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0648\u0627\u0644\u0645\u0639\u0645\u0631\u0648\u0646<span dir=\"LTR\"> (Supercentenarians) <\/span>\u0647\u0645 \u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0631\u064a\u062f\u0629 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633 \u0646\u0627\u062f\u0631\u0629 \u0644\u0644\u063a\u0627\u064a\u0629. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u064a\u0642\u062f\u0631 \u0639\u0644\u0645\u0627\u0621 \u0627\u0644\u0633\u0643\u0627\u0646 \u0641\u064a \u0643\u0646\u062f\u0627 \u0623\u0646 \u0641\u0631\u0635\u0629 \u0627\u0644\u0639\u064a\u0634 \u0644\u0623\u0643\u062b\u0631 \u0645\u0646 110 \u0639\u0627\u0645\u064b\u0627 \u0647\u064a \u0623\u0642\u0644 \u0645\u0646 1 \u0644\u0643\u0644 \u0645\u0627\u0626\u0629 \u0623\u0644\u0641. \u0623\u0645\u0627 \u0641\u064a \u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u0641\u064a \u0639\u0627\u0645 2015\u060c \u0648\u0647\u0646\u0627\u0643 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0648\u0627\u062d\u062f \u0648\u0633\u062a\u064a\u0646 \u0623\u0644\u0641 \u0634\u062e\u0635 \u064a\u0632\u064a\u062f \u0639\u0645\u0631\u0647\u0645 \u0639\u0646 100 \u0639\u0627\u0645\u060c \u0648\u0641\u0642\u0637 146 \u0634\u062e\u0635\u064b\u0627 \u0641\u0648\u0642 \u0633\u0646 110. \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0623\u0646 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0643\u0627\u0646\u0648\u0627 \u064a\u062a\u0645\u062a\u0639\u0648\u0646 \u0628\u0645\u0642\u0627\u0648\u0645\u0629 \u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0645\u064a\u062a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0627\u0644\u0633\u0643\u062a\u0629 \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629 \u0648\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645 \u0643\u0644\u0647\u0627. \u0648\u0623\u062f\u0651\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0625\u0644\u0649 \u0641\u0643\u0631\u0629 \u0623\u0646\u0647 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u062f\u064a\u0647\u0645 \u0646\u0638\u0627\u0645 \u0645\u0646\u0627\u0639\u0629 \u0642\u0648\u064a \u0628\u0634\u0643\u0644 \u062e\u0627\u0635<span dir=\"LTR\">.<\/span> \u0648\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0623\u0633\u0628\u0627\u0628 \u0648\u0631\u0627\u0621 \u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0644\u062f\u0649 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0645\u0627\u0621 \u0645\u0646 \u0645\u0631\u0643\u0632<span dir=\"LTR\"> RIKEN <\/span>\u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u062a\u0643\u0627\u0645\u0644\u064a\u0629<span dir=\"LTR\"> (IMS) <\/span>\u0648\u0643\u0644\u064a\u0629 \u0627\u0644\u0637\u0628 \u0628\u062c\u0627\u0645\u0639\u0629 \u0643\u064a\u0648 \u0641\u064a \u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a<span dir=\"LTR\"> RNA <\/span>\u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0648\u0627\u062d\u062f\u0629 \u062d\u064a\u062b \u0648\u064f\u062c\u062f \u0623\u0646 \u0643\u0628\u0627\u0631 \u0627\u0644\u0633\u0646 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 (\u0641\u0648\u0642 \u0633\u0646 110)<span dir=\"LTR\"> Supercentenarians&nbsp;<\/span> \u0644\u062f\u064a\u0647\u0645 \u0639\u062f\u062f \u0623\u0643\u062b\u0631 \u0645\u0646 \u0646\u0648\u0639 \u0645\u062d\u062f\u062f \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u064a\u0633\u0645\u0649 \u062e\u0644\u0627\u064a\u0627<span dir=\"LTR\"> CD4 <\/span>\u0627\u0644\u0642\u0627\u062a\u0644\u0629<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0644\u0644\u0625\u062c\u0627\u0628\u0629 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0633\u0624\u0627\u0644\u060c \u0623\u062c\u0631\u064a \u0628\u062d\u062b \u0642\u0627\u0645 \u0641\u064a\u0647 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0628\u062a\u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0631\u0629 \u0628\u0627\u0644\u062f\u0645 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0645\u062a\u0637\u0648\u0639\u064a\u0646 \u0627\u0644\u0635\u063a\u0627\u0631 \u0648\u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646. \u0648\u0642\u062f \u062a\u0645 \u062f\u0631\u0627\u0633\u0629 \u0639\u062f\u062f <span dir=\"LTR\">41,208<\/span> \u062e\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0632\u064a\u062f \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0639\u0646 100 \u0639\u0627\u0645 (\u0645\u0627 \u0645\u062a\u0648\u0633\u0637\u0647 <span dir=\"LTR\">5,887<\/span> \u0644\u0643\u0644 \u0641\u0631\u062f) \u062a\u0645 \u062a\u062c\u0645\u064a\u0639\u0647\u0645 \u0645\u0646 \u0633\u0628\u0639\u0629 \u0645\u0642\u0627\u0637\u0639\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u064a\u0627\u0628\u0627\u0646. \u0648\u0628\u0627\u0644\u062a\u0648\u0627\u0632\u064a \u062a\u0645 \u062a\u062c\u0645\u064a\u0639 <span dir=\"LTR\">19,994<\/span> \u062e\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0635\u063a\u0631 \u0633\u0646\u0627\u064b (\u0628\u0645\u0639\u062f\u0644 <span dir=\"LTR\">3,999<\/span> \u0644\u0643\u0644 \u0641\u0631\u062f) \u062a\u0645 \u062a\u062c\u0645\u064a\u0639\u0647\u0645 \u0645\u0646 \u062e\u0645\u0633 \u0645\u0642\u0627\u0637\u0639\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 \u0627\u0644\u062e\u0645\u0633\u064a\u0646\u064a\u0627\u062a \u0625\u0644\u0649 \u0627\u0644\u062b\u0645\u0627\u0646\u064a\u0646\u0627\u062a. \u0648\u0642\u062f \u0648\u062c\u062f \u0627\u0644\u0641\u0631\u064a\u0642 \u0627\u0644\u0628\u062d\u062b\u064a \u0623\u0646\u0647 \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0639\u062f\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0643\u0627\u0646 \u0623\u0642\u0644 \u0641\u064a \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646\u060c \u0641\u0625\u0646 \u0639\u062f\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0643\u0627\u0646 \u0647\u0648 \u0646\u0641\u0633\u0647 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0641\u064a \u0643\u0644\u0627 \u0645\u0646 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629 (\u0627\u0644\u0634\u0627\u0628\u0629)\u060c \u0648\u0644\u0643\u0646 \u0644\u0648\u062d\u0638 \u0623\u0646 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0645\u0633\u062a\u0648\u0649 \u0639\u0627\u0644 \u062c\u062f\u064b\u0627 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0635\u0644 \u0623\u062d\u064a\u0627\u0646\u064b\u0627 \u0625\u0644\u0649 80 \u0628\u0627\u0644\u0645\u0627\u0626\u0629 \u0645\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0628\u0627\u0644\u062f\u0645 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0640 10 \u0623\u0648 20 \u0628\u0627\u0644\u0645\u0627\u0626\u0629 \u0641\u0642\u0637 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062e\u0631\u0649. \u0648\u0628\u062a\u062d\u0644\u064a\u0644 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u062c\u062f \u0623\u0646\u0647\u0627 \u0645\u0646 \u0646\u0648\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644 (\u0639\u0634\u0645\u0627\u0648\u064a) \u0645\u0645\u0627 \u064a\u0639\u0646\u064a \u0623\u0646 \u0644\u0647\u0627 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0642\u062a\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u062e\u0631\u0649<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0648\u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0646\u0648\u0639\u0627\u0646\u060c \u0623\u062d\u062f\u0647\u0645\u0627 \u064a\u062d\u0645\u0644 \u0627\u0644\u0639\u0644\u0627\u0645\u0629<span dir=\"LTR\"> CD4 <\/span>\u0648\u0627\u0644\u0622\u062e\u0631 \u064a\u062d\u0645\u0644 \u0627\u0644\u0639\u0644\u0627\u0645\u0629<span dir=\"LTR\"> CD8 <\/span>\u0639\u0644\u0649 \u0633\u0637\u062d\u0647\u0627. \u0648\u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u062a\u0643\u0648\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0639\u0644\u0627\u0645\u0627\u062a<span dir=\"LTR\"> CD8 <\/span>\u0647\u064a \u0627\u0644\u062a\u064a \u062a\u0642\u062a\u0644 \u0627\u0644\u0639\u062f\u0648 \u0627\u0644\u063a\u0631\u064a\u0628 \u0648\u0644\u0648 \u0643\u0627\u0646 \u0645\u062e\u062a\u0628\u0626\u0627\u064b \u0641\u064a \u0627\u0644\u062e\u0644\u064a\u0629 \u0628\u0639\u062f \u0623\u0646 \u064a\u063a\u0632\u0648 \u0627\u0644\u062c\u0633\u0645 \u0648\u0630\u0644\u0643 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u0637\u0644\u0627\u0642 <span dir=\"LTR\"><a href=\"https:\/\/ar.wikipedia.org\/w\/index.php?title=%D8%AE%D9%84%D9%8A%D8%A9_%D8%AD%D8%A8%D9%8A%D8%A8%D9%8A%D8%A9&amp;action=edit&amp;redlink=1\" title=\"\u062e\u0644\u064a\u0629 \u062d\u0628\u064a\u0628\u064a\u0629 (\u0627\u0644\u0635\u0641\u062d\u0629 \u063a\u064a\u0631 \u0645\u0648\u062c\u0648\u062f\u0629)\"><span dir=\"RTL\">\u062d\u0628\u064a\u0628\u0627\u062a<\/span><\/a><\/span>&nbsp; \u0635\u063a\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u0632\u064a\u0645\u0627\u062a&nbsp; \u062a\u0633\u0645\u0649 <span dir=\"LTR\"><a href=\"https:\/\/ar.wikipedia.org\/w\/index.php?title=%D8%A8%D8%B1%D9%81%D9%88%D8%B1%D9%8A%D9%86&amp;action=edit&amp;redlink=1\" title=\"\u0628\u0631\u0641\u0648\u0631\u064a\u0646 (\u0627\u0644\u0635\u0641\u062d\u0629 \u063a\u064a\u0631 \u0645\u0648\u062c\u0648\u062f\u0629)\"><span dir=\"RTL\">\u0628\u0631\u0641\u0648\u0631\u064a\u0646<\/span><\/a><\/span><span dir=\"LTR\">&nbsp;Perforin&nbsp;<\/span><span dir=\"LTR\"><a href=\"https:\/\/ar.wikipedia.org\/wiki\/%D8%BA%D8%B1%D8%A7%D9%86%D8%B2%D9%8A%D9%85\" title=\"\u063a\u0631\u0627\u0646\u0632\u064a\u0645\"><span dir=\"RTL\">\u0648\u063a\u0631\u0627\u0646\u0632\u064a\u0645<\/span><\/a><\/span><span dir=\"LTR\">&nbsp;Granzyme <\/span>\u062a\u0633\u0628\u0628 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0623\u0646 \u0644\u0647\u0627 \u0642\u062f\u0631\u0629 \u0639\u0627\u0644\u064a\u0629 \u0639\u0644\u0649 \u0627\u062e\u062a\u0631\u0627\u0642 \u0648\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0644\u0648\u064a<span dir=\"LTR\"> .<\/span> \u0623\u0645\u0627 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0639\u0644\u0627\u0645\u0629<span dir=\"LTR\"> CD4 <\/span>\u0641\u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0627 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0642\u062a\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0648\u0644\u0643\u0646\u0647\u0627 \u062a\u0642\u062f\u0645 \u064a\u062f \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644\u0629 \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u0641\u0631\u0627\u0632 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u0646\u0645\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627. \u0648\u0644\u0630\u0644\u0643 \u0627\u0639\u062a\u0642\u062f \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u0628\u0627\u062f\u0626 \u0627\u0644\u0623\u0645\u0631 \u0623\u0646 \u0632\u064a\u0627\u062f\u0629 \u0623\u0639\u062f\u0627\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0635\u0641\u0627\u062a \u0627\u0644\u0642\u062a\u0644 \u0647\u0630\u0647 \u0631\u0628\u0645\u0627 \u064a\u0643\u0648\u0646 \u0646\u062a\u064a\u062c\u0629 \u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062d\u0627\u0645\u0644\u0629 \u0644\u0644\u0640\u0639\u0644\u0627\u0645\u0627\u062a <span dir=\"LTR\">&nbsp;CD8&nbsp; <\/span>\u0644\u0623\u0646\u0647\u0627 \u0647\u064a \u0627\u0644\u0645\u0646\u0648\u0637 \u0628\u0647\u0627 \u0639\u0645\u0644\u064a\u0629 \u0642\u062a\u0644 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u063a\u0631\u064a\u0628 \u0623\u0648 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u0635\u0627\u0628\u0629<span dir=\"LTR\"> .<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0644\u0643\u0646 \u0627\u0644\u063a\u0631\u064a\u0628 \u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0644\u0623\u0645\u0631 \u0644\u064a\u0633 \u0643\u0630\u0644\u0643. \u0641\u0642\u062f \u0648\u062c\u062f \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627<span dir=\"LTR\"> CD4 <\/span>\u0641\u064a \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0647\u064a \u0627\u0644\u062a\u064a \u0627\u0632\u062f\u0627\u062f\u062a \u0623\u0639\u062f\u0627\u062f\u0647\u0627 \u0648\u0647\u064a \u0627\u0644\u062a\u064a \u0627\u0643\u062a\u0633\u0628\u062a \u0635\u0641\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644\u0629 (\u0639\u0634\u0645\u0627\u0648\u064a \u062c\u062f\u064a\u062f) \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0625\u0637\u0644\u0627\u0642 \u0623\u0646\u0632\u064a\u0645\u0627\u062a&nbsp; <span dir=\"LTR\"><a href=\"https:\/\/ar.wikipedia.org\/w\/index.php?title=%D8%A8%D8%B1%D9%81%D9%88%D8%B1%D9%8A%D9%86&amp;action=edit&amp;redlink=1\" title=\"\u0628\u0631\u0641\u0648\u0631\u064a\u0646 (\u0627\u0644\u0635\u0641\u062d\u0629 \u063a\u064a\u0631 \u0645\u0648\u062c\u0648\u062f\u0629)\"><span dir=\"RTL\">\u0628\u0631\u0641\u0648\u0631\u064a\u0646<\/span><\/a><\/span><span dir=\"LTR\">&nbsp;Perforin&nbsp;<\/span><span dir=\"LTR\"><a href=\"https:\/\/ar.wikipedia.org\/wiki\/%D8%BA%D8%B1%D8%A7%D9%86%D8%B2%D9%8A%D9%85\" title=\"\u063a\u0631\u0627\u0646\u0632\u064a\u0645\"><span dir=\"RTL\">\u0648\u063a\u0631\u0627\u0646\u0632\u064a\u0645<\/span><\/a><\/span><span dir=\"LTR\">Granzyme <\/span>. \u0648\u0645\u0646 \u0627\u0644\u0645\u062b\u064a\u0631 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645\u060c \u0639\u0646\u062f\u0645\u0627 \u0646\u0638\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u062f\u0645 \u0627\u0644\u0645\u062a\u0628\u0631\u0639\u064a\u0646 \u0627\u0644\u0634\u0628\u0627\u0628\u060c \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0639\u062f\u062f \u0642\u0644\u064a\u0644 \u0646\u0633\u0628\u064a\u0627 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0627\u0644\u0639\u0644\u0627\u0645\u0627\u062a<span dir=\"LTR\">CD4 <\/span>\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0647\u0630\u0627 \u0644\u0645 \u064a\u0643\u0646 \u0639\u0644\u0627\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0634\u0628\u0627\u0628 \u0628\u0644 \u0647\u0648 \u0633\u0645\u0629 \u062e\u0627\u0635\u0629 \u0644\u0644\u0645\u0639\u0645\u0631\u064a\u0646. \u0648\u0644\u0644\u0646\u0638\u0631 \u0641\u064a \u0643\u064a\u0641\u064a\u0629 \u0625\u0646\u062a\u0627\u062c \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062e\u0627\u0635\u0629\u060c \u0642\u0627\u0645 \u0627\u0644\u0641\u0631\u064a\u0642 \u0628\u0641\u062d\u0635 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0645\u0646 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0628\u0627\u0644\u062a\u0641\u0635\u064a\u0644\u060c \u0648\u0648\u062c\u062f \u0623\u0646\u0647\u0627 \u0646\u0634\u0623\u062a \u0645\u0646 \u0646\u0641\u0633 \u0627\u0644\u0646\u0633\u0644\u060c \u0645\u0645\u0627 \u064a\u0639\u0646\u064a \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u0631\u064a\u0628\u0629 \u0646\u0634\u0623\u062a \u0645\u0646 \u0633\u0644\u0641 \u0648\u0627\u062d\u062f \u0641\u064a \u0627\u0644\u0623\u0635\u0644<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0648\u0642\u062f \u0623\u0634\u0627\u0631 \u0643\u0648\u0633\u0648\u0643\u064a \u0647\u0627\u0634\u064a\u0645\u0648\u062a\u0648 \u0645\u0624\u0644\u0641 \u0623\u0648\u0644 \u0644\u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0648\u064a\u0639\u0645\u0644 \u0643\u0628\u0627\u062d\u062b \u0641\u064a \u0645\u0639\u0647\u062f<span dir=\"LTR\"> IMS <\/span>\u0628\u0627\u0644\u064a\u0627\u0628\u0627\u0646 &quot;\u0644\u0642\u062f \u0643\u0646\u0627 \u0645\u0647\u062a\u0645\u064a\u0646 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0628\u062f\u0631\u0627\u0633\u0629 \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0639\u0645\u0651\u0631\u0629 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633\u060c \u0644\u0623\u0646\u0646\u0627 \u0646\u0639\u062a\u0628\u0631\u0647\u0645 \u0646\u0645\u0648\u0630\u062c\u064b\u0627 \u062c\u064a\u062f\u064b\u0627 \u0644\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0628\u0644\u0627 \u0623\u0645\u0631\u0627\u0636\u060c \u0648\u0647\u0630\u0627 \u0623\u0645\u0631 \u0645\u0647\u0645 \u0641\u064a \u0645\u062c\u062a\u0645\u0639\u0627\u062a \u0645\u062b\u0644 \u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u062d\u064a\u062b \u0644\u0648\u062d\u0638 \u0641\u064a \u0627\u0644\u0639\u0642\u0648\u062f \u0627\u0644\u0645\u0627\u0636\u064a\u0629 \u0623\u0646 \u0645\u0639\u062f\u0644 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u064a\u0633\u064a\u0631 \u0628\u0633\u0631\u0639\u0629 \u0639\u0643\u0633 \u0645\u0627 \u0643\u0627\u0646 \u0641\u064a \u0627\u0644\u0639\u0642\u0648\u062f \u0627\u0644\u0633\u0627\u0628\u0642\u0629&quot;. \u0648\u0623\u0636\u0627\u0641 \u0646\u0627\u0626\u0628 \u0645\u062f\u064a\u0631 \u0645\u0639\u0647\u062f<span dir=\"LTR\"> IMS <\/span>\u060c \u0628\u064a\u064a\u0631\u0648 \u0643\u0627\u0631\u0646\u0634\u064a \u060c \u0623\u062d\u062f \u0642\u0627\u062f\u0629 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a\u060c &quot;\u0646\u062a\u0627\u0626\u062c \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f\u0646\u0627 \u0639\u0644\u0649 \u0641\u0647\u0645 \u0644\u0645\u0627\u0630\u0627 \u0647\u0646\u0627\u0643 \u0628\u0639\u0636 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0647\u0645 \u0623\u0643\u062b\u0631 \u0639\u0631\u0636\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636. \u0647\u0630\u0627 \u0645\u062b\u064a\u0631 \u0644\u0623\u0646 \u0627\u0644\u0628\u062d\u062b \u0642\u062f\u0645 \u0644\u0646\u0627 \u0631\u0624\u0649 \u062c\u062f\u064a\u062f\u0629 \u062d\u0648\u0644 \u0643\u064a\u0641\u064a\u0629 \u062a\u0645\u0643\u0646 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u064a\u0634\u0648\u0646 \u062d\u064a\u0627\u0629 \u0637\u0648\u064a\u0644\u0629 \u062c\u062f\u064b\u0627 \u0645\u0646 \u062d\u0645\u0627\u064a\u0629 \u0623\u0646\u0641\u0633\u0647\u0645 \u0645\u0646 \u062d\u0627\u0644\u0627\u062a \u0645\u062b\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0648\u0627\u0644\u0633\u0631\u0637\u0627\u0646<span dir=\"LTR\">&quot;<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u062a\u0639\u0645\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0645\u0646 \u0646\u0648\u0639<span dir=\"LTR\"> CD4 <\/span>(\u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629) \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u0648\u0644\u064a\u062f \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a (\u0648\u0647\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0647\u0645\u0629) \u0627\u0644\u062a\u064a \u062a\u0645\u062f \u064a\u062f \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0648\u0645\u0646\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644\u0629. \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627<span dir=\"LTR\"> CD8 <\/span>\u062a\u0642\u0648\u0645 \u0628\u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0642\u062a\u0644 (\u0639\u0634\u0645\u0627\u0648\u064a \u0627\u0644\u0645\u0646\u0627\u0639\u0629). \u0648\u0644\u0630\u0644\u0643 \u0641\u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0644\u062c\u0645\u0639 \u0628\u064a\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u064a\u0632\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0641\u064a \u062e\u0644\u064a\u0629 \u0648\u0627\u062d\u062f\u0629 \u064a\u0633\u0645\u062d \u0644\u0647\u0645 \u0628\u0623\u0646 \u064a\u0643\u0648\u0646\u0648\u0627 \u0628\u0635\u062d\u0629 \u062c\u064a\u062f\u0629 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635. \u0646\u062d\u0646 \u0646\u0639\u062a\u0642\u062f \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u063a\u064a\u0631 \u0627\u0644\u0645\u0623\u0644\u0648\u0641 \u0646\u0633\u0628\u064a\u064b\u0627 \u0641\u064a \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u0641\u0631\u0627\u062f\u060c \u062d\u062a\u0649 \u0627\u0644\u0634\u0628\u0627\u0628\u060c \u0645\u0641\u064a\u062f \u0641\u064a \u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0623\u0648\u0644\u0627 \u0628\u0623\u0648\u0644\u060c \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0647\u0645\u064b\u0627 \u0644\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0648\u0647\u0643\u0630\u0627 \u064a\u0628\u064a\u0646 \u0644\u0646\u0627 \u0627\u0644\u0639\u0644\u0645 \u0623\u0646 \u0648\u0631\u0627\u0621 \u0643\u0644 \u0634\u064a\u0621 \u0633\u0628\u0628 \u0648\u0644\u0648 \u062c\u0647\u0644\u0646\u0627\u0647 \u0641\u064a \u062d\u064a\u0646\u0647. \u0641\u062a\u0645\u062a\u0639 \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0628\u0635\u062d\u0629 \u062c\u064a\u062f\u0629 \u0631\u063a\u0645 \u0634\u064a\u062e\u0648\u062e\u062a\u0647\u0645 \u0648\u0631\u0627\u0621\u0647 \u0633\u0628\u0628 \u0648\u0647\u0648 \u0648\u062c\u0648\u062f \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0630\u064a \u0627\u0643\u062a\u0633\u0628 \u0635\u0641\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0645 \u062a\u0643\u0646 \u062a\u062a\u0645\u062a\u0639 \u0628\u0647\u0627\u060c \u0635\u0641\u0627\u062a \u062a\u0645\u0643\u0646\u0647\u0627 \u0645\u0646 \u0642\u062a\u0644 \u0623\u0639\u062f\u0627\u0621 \u0627\u0644\u062c\u0633\u0645 \u0643\u0645\u0627 \u062a\u0641\u0639\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0627\u062a\u0644\u0629 (\u0639\u0634\u0645\u0627\u0648\u064a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a). \u0648\u0647\u0643\u0630\u0627 \u0623\u0635\u0628\u062d \u0641\u064a \u0627\u0644\u0645\u0639\u0645\u0631\u064a\u0646 \u0639\u0634\u0645\u0627\u0648\u064a \u0623\u0633\u0627\u0633\u064a \u0648\u0639\u0634\u0645\u0627\u0648\u064a \u062c\u062f\u064a\u062f \u0644\u062a\u0632\u064a\u062f \u0627\u0644\u0642\u0648\u0629 \u0641\u064a \u0642\u062a\u0644 \u0627\u0644\u0623\u0639\u062f\u0627\u0621. \u0648\u0647\u0646\u0627 \u064a\u0643\u0645\u0646 \u0627\u0644\u0633\u0628\u0628\u060c \u0648\u0625\u0630\u0627 \u0639\u064f\u0631\u0641 \u0627\u0644\u0633\u0628\u0628 \u0628\u0637\u0644 \u0627\u0644\u0639\u062c\u0628. \u0648\u0645\u0627 \u0632\u0627\u0644 \u0645\u0627 \u062e\u0641\u064a \u0645\u0646 \u0627\u0644\u0639\u0644\u0645 \u0623\u0643\u062b\u0631 \u0645\u0645\u0627 \u0639\u0644\u0645\u0646\u0627\u0647<span dir=\"LTR\">.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\"><strong><span style=\"color:#d89e30;\">\u0627\u0644\u0645\u0631\u0627\u062c\u0639<\/span><\/strong><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\"><strong>&#8211; \u062a\u0645 \u0646\u0634\u0631 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0645\u0634\u0627\u0631 \u0627\u0644\u064a\u0647 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0642\u0627\u0644 \u0641\u064a \u0645\u062c\u0644\u0629 \u0648\u0642\u0627\u0626\u0639 \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645<span dir=\"LTR\">(PNAS) <\/span>\u060c \u0628\u0627\u0644\u062a\u0639\u0627\u0648\u0646 \u0645\u0639 \u0639\u0644\u0645\u0627\u0621 \u0645\u0646 \u0645\u0631\u0643\u0632<span dir=\"LTR\"> RIKEN <\/span>\u0644\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u062a\u0643\u0627\u0645\u0644\u064a\u0629 \u0648\u0643\u0644\u064a\u0629 \u0627\u0644\u0637\u0628 \u0628\u062c\u0627\u0645\u0639\u0629 \u0643\u064a\u0648<span dir=\"LTR\">.<\/span><\/strong><\/p>\n<ul dir=\"ltr\">\n<li style=\"text-align: justify;\">Hashimoto et al. (2019) <a href=\"https:\/\/www.pnas.org\/content\/116\/48\/24242\">Single-cell transcriptomics reveals expansion of cytotoxic cd4 t cells in supercentenarians<\/a>. Proc Natl Acad Sci USA.<\/li>\n<\/ul>\n<p dir=\"RTL\" style=\"text-align: justify;\">&nbsp;<\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\"><strong>&#8211; \u062a\u0645 \u0627\u0644\u062a\u0639\u0644\u064a\u0642 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0628\u0627\u0644\u0644\u063a\u0629 \u0627\u0644\u0627\u0646\u062c\u0644\u064a\u0632\u064a\u0629 \u0641\u064a \u062e\u0628\u0631 \u062a\u0645 \u0646\u0634\u0631\u0647 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u064a\u0627\u0628\u0627\u0646\u064a\u0629 \u0627\u0644\u0627\u062a\u064a\u0629<span dir=\"LTR\">:<\/span><\/strong><\/p>\n<ul dir=\"ltr\">\n<li style=\"text-align: justify;\"><a href=\"https:\/\/itaintmagic.riken.jp\/hot-off-the-press\/longevity-in-supercentenarians-linked-to-cytotoxic-t-cells\/\">https:\/\/itaintmagic.riken.jp\/hot-off-the-press\/longevity-in-supercentenarians-linked-to-cytotoxic-t-cells\/<\/a><\/li>\n<li style=\"text-align: justify;\"><a href=\"https:\/\/www.riken.jp\/en\/news_pubs\/research_news\/2019\/20191113_1\/index.html\">https:\/\/www.riken.jp\/en\/news_pubs\/research_news\/2019\/20191113_1\/index.html<\/a><\/li>\n<\/ul>\n<p dir=\"ltr\" style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\">\n<span style=\"color:#d89e30;\">\u0627\u0644\u0628\u0631\u064a\u062f \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0644\u0644\u0643\u0627\u062a\u0628:<\/span> <a href=\"mailto:mohamedlabibsalem@yahoo.com\">mohamedlabibsalem@yahoo.com<\/a><\/p>\n","protected":false},"featured_media":0,"menu_order":907,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[11163,11469,11830,13356,13355,5949],"class_list":["post-15666","articles","type-articles","status-publish","hentry","tag-11163","tag-11469","tag-11830","tag-13356","tag-13355","tag-tag-200"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0647\u0644 \u0639\u0634\u0645\u0627\u0648\u064a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0639\u0644\u0627\u0645\u0629 \u0639\u0644\u0649 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631\u061f! 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