{"id":15553,"date":"2019-03-26T12:21:26","date_gmt":"2019-03-26T12:21:26","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-1363\/"},"modified":"2019-03-26T12:21:26","modified_gmt":"2019-03-26T12:21:26","slug":"article-detail-1363","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-15553\/","title":{"rendered":"\u0628\u0643\u062a\u0631\u064a\u0627 \u0627\u0644\u0644\u062b\u0629 \u0648\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631"},"content":{"rendered":"<p dir=\"RTL\" style=\"text-align: justify;\"><span style=\"color:#008080;\">\u062a\u0645\u062b\u0644 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0644\u062b\u0629 \u0645\u0634\u0643\u0644\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0643\u0644\u0647\u060c \u0641\u0637\u0628\u0642\u0627\u064b \u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0633\u062c\u0644\u0647\u0627 \u0627\u0644\u0645\u0639\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a \u0644\u0623\u0628\u062d\u0627\u062b \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u0648\u0627\u0644\u0642\u062d\u0641 \u0641\u0625\u0646 &nbsp;8,52% \u0645\u0646 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 20 \u0625\u0644\u0649 64 \u0639\u0627\u0645\u0627\u064b \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0648\u062d\u062f\u0647\u0627 \u064a\u0635\u0627\u0628\u0648\u0646 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0644\u062b\u0629 \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0625\u0646\u062a\u0634\u0627\u0631 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645. \u0648\u062a\u062a\u0631\u062a\u0628 \u0639\u0644\u064a\u0647 \u0645\u0634\u0627\u0643\u0644 \u0635\u062d\u064a\u0629 \u0644\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646\u060c \u0623\u0642\u0644\u0647\u0627 \u0633\u0642\u0648\u0637 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u0648\u0623\u062e\u0637\u0631\u0647\u0627 \u0645\u0631\u0636 \u0627\u0644\u0633\u0631\u0637\u0627\u0646.<\/span><\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0643\u0634\u0641 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u062d\u062f\u064a\u062b\u0627\u064b \u0623\u0646\u0647 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0644\u0643 \u0627\u0644\u0623\u0645\u0631\u0627\u0636\u060c \u0641\u0625\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u062a\u0624\u0643\u062f \u0628\u0623\u062f\u0644\u0629 \u0648\u0627\u0636\u062d\u0629 \u0623\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0644\u062b\u0629 \u062d\u0627\u0644 \u0648\u062c\u0648\u062f\u0647\u0627 \u0648\u0646\u0645\u0648\u0647\u0627 \u062a\u0633\u0627\u0647\u0645 \u0641\u064a \u0625\u0641\u0631\u0627\u0632 \u0648\u0645\u0631\u0627\u0643\u0645\u0629 \u0645\u0648\u0627\u062f \u0633\u0627\u0645\u0629 \u062a\u0635\u0644 \u0625\u0644\u0649 \u0627\u0644\u0645\u062e\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0633\u0627\u0645\u0629 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0646\u0627\u0645\u064a \u0648\u0638\u0647\u0648\u0631 \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0641\u064a \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646. \u062e\u0644\u0627\u0644 \u0628\u062d\u0648\u062b\u0647\u0645 \u0644\u0625\u064a\u062c\u0627\u062f \u0639\u0644\u0627\u062c \u0644\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u0644\u0627\u062d\u0638 \u0628\u0627\u062d\u062b\u0648\u0646 \u0645\u0646 \u0634\u0631\u0643\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 &quot;\u0643\u0648\u0631\u062a\u0643\u0633\u064a\u0645 <span dir=\"LTR\">Cortexyme<\/span>&quot; &nbsp;\u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0645\u0624\u0643\u062f\u0629 \u0628\u064a\u0646 \u0628\u0643\u062a\u0631\u064a\u0627 \u0645\u0631\u0636 \u0627\u0644\u0644\u062b\u0629 \u0648\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u0648\u0646\u064f\u0634\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u062a\u0644\u0643 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0645\u062c\u0644\u0629 &quot;\u062a\u0642\u062f\u0645 \u0627\u0644\u0639\u0644\u0645 <span dir=\"LTR\">Science Advances<\/span> &quot; \u064a\u0646\u0627\u064a\u0631 2019.<\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u062a\u0646\u0627\u0648\u0644 \u0641\u0631\u064a\u0642 \u0627\u0644\u0628\u062d\u062b \u0646\u0648\u0639\u0627\u064b \u0648\u0627\u062d\u062f\u0627\u064b \u0641\u0642\u0637 \u0645\u0646 \u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u0641\u0645 \u0627\u0644\u0644\u0627\u0647\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0633\u0627\u0644\u0628\u0629 \u0644\u0635\u0628\u063a\u0629 \u062c\u0631\u0627\u0645 \u0648\u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0645\u0631\u0636 \u0627\u0644\u0644\u062b\u0629\u060c \u0648\u0647\u064a &quot;\u0628\u0631\u0648\u0641\u064a\u0631\u0648\u0645\u0648\u0646\u0627\u0633 \u062c\u064a\u0646\u062c\u064a\u0641\u0627\u0644\u064a\u0633 <span dir=\"LTR\">Prophyromonas gingivalis<\/span> &quot; \u0648\u0627\u0644\u062a\u064a \u0644\u0641\u062a\u062a \u0625\u0646\u062a\u0628\u0627\u0647 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0628\u0648\u062c\u0648\u062f\u0647\u0627 \u0641\u064a \u0623\u0645\u062e\u0627\u062e \u0645\u0631\u0636\u0649 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631. \u0648\u0628\u0625\u0633\u062a\u062e\u062f\u0627\u0645 <img decoding=\"async\" alt=\"\" src=\"http:\/\/www.arsco.org\/wp-content\/uploads\/EditorImages\/NewImages\/12223260319122040.jpg\" style=\"margin: 5px; width: 489px; height: 301px; float: left;\" \/>\u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0643\u0646\u0645\u0648\u0630\u062c \u0644\u0644\u0625\u062e\u062a\u0628\u0627\u0631\u0627\u062a\u060c \u0648\u0628\u0639\u062f \u062d\u0642\u0646\u0647\u0627 \u0628\u0628\u0643\u062a\u0631\u064a\u0627 \u0628\u0631\u0648\u0641\u064a\u0631\u0648\u0645\u0648\u0646\u0627\u0633 \u062c\u064a\u0646\u062c\u064a\u0641\u0627\u0644\u064a\u0633\u060c \u0643\u0634\u0641\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0639\u0646 \u0648\u062c\u0648\u062f \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0628\u064a\u062a\u0627 \u0623\u0645\u064a\u0644\u0648\u064a\u062f <span dir=\"LTR\">beta-amyloid<\/span> \u0627\u0644\u0633\u0627\u0645\u0651\u0629 \u0648\u0642\u062f \u0623\u064f\u0641\u0631\u0632\u062a \u0641\u064a \u0623\u0645\u062e\u0627\u062e \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0628\u0643\u062a\u0631\u064a\u0627\u060c \u0648\u062a\u0644\u0643 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u064a\u0639\u062a\u0628\u0631\u0647\u0627 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0645\u0624\u0634\u0631 \u0639\u0644\u0649 \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u062f\u0647\u0648\u0631 \u0648\u0641\u0642\u062f\u0627\u0646 \u0641\u064a \u0627\u0644\u0630\u0627\u0643\u0631\u0629 <span dir=\"LTR\">neurodegenerative condition<\/span> \u0648\u0645\u0646 \u062b\u0645\u0651 \u062a\u0639\u064a\u0642 \u062a\u0648\u0627\u0635\u0644 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062e \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0641\u064a\u0645\u0627 \u0628\u064a\u0646\u0647\u0627.<\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\">\u0642\u0627\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u064a\u0636\u0627\u064b \u0628\u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0625\u0646\u0632\u064a\u0645 \u0628\u0643\u062a\u0631\u064a\u0627 \u0628\u0631\u0648\u0641\u064a\u0631\u0648\u0645\u0648\u0646\u0627\u0633 \u062c\u064a\u0646\u062c\u064a\u0641\u0627\u0644\u064a\u0633 \u0627\u0644\u0633\u0627\u0645 \u0648\u0647\u0648 &quot;\u062c\u064a\u0646\u062c\u064a\u0628\u0627\u0646\u0632 <span dir=\"LTR\">gingipains<\/span> &quot; \u062d\u064a\u062b \u062a\u0628\u064a\u0646 \u0648\u062c\u0648\u062f\u0647 \u0628\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0629 \u0641\u064a \u0623\u0645\u062e\u0627\u062e \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0648\u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u0648\u064a\u0631\u062a\u0628\u0637 \u0647\u0630\u0627 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0645\u0639 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062a\u0633\u0645\u0649 &quot;\u062a\u0627\u0648 \u0648\u0623\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 <span dir=\"LTR\">tau and ubiquitin<\/span>&quot; \u0648\u0647\u064a \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0623\u062b\u0628\u062a \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0623\u0646 \u0644\u0647\u0627 \u0635\u0644\u0629 \u0628\u062a\u0646\u0627\u0645\u064a \u0648\u062d\u062f\u0648\u062b \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u062d\u064a\u062b \u0623\u0643\u062f\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u064a\u0636\u0627\u064b \u0639\u0646 \u0623\u0646 \u0625\u0646\u0632\u064a\u0645 \u062c\u064a\u0646\u062c\u064a\u0628\u0627\u0646\u0632 \u064a\u0641\u0627\u0642\u0645 \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0633\u0627\u0645 \u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u062a\u0627\u0648 <span dir=\"LTR\">tau<\/span>.<\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\"><img decoding=\"async\" alt=\"\" src=\"http:\/\/www.arsco.org\/wp-content\/uploads\/EditorImages\/NewImages\/525260319122108.png\" style=\"margin: 5px; width: 489px; height: 301px; float: left;\" \/>\u0642\u0627\u0645 \u0641\u0631\u064a\u0642 \u0627\u0644\u0628\u062d\u062b \u0628\u0648\u0636\u0639 \u0625\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0645\u0646 \u0623\u062c\u0644 \u062a\u0635\u0645\u064a\u0645 \u0648\u0625\u0646\u062a\u0627\u062c \u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0628\u0647\u062f\u0641 \u062a\u0639\u0637\u064a\u0644 \u0623\u0648 \u0648\u0642\u0641 \u0646\u0634\u0627\u0637 \u0625\u0646\u0632\u064a\u0645 \u062c\u064a\u0646\u062c\u064a\u0628\u0627\u0646\u0632 \u0627\u0644\u0630\u064a \u062a\u0641\u0631\u0632\u0647 \u0628\u0643\u062a\u0631\u064a\u0627 \u0627\u0644\u0644\u062b\u0629\u060c \u0648\u062a\u0648\u0635\u0644\u0648\u0627 \u0628\u0639\u062f \u062a\u062c\u0627\u0631\u0628 \u0639\u062f\u064a\u062f\u0629 \u0625\u0644\u0649 \u0645\u0631\u0643\u0628 \u064a\u0633\u0645\u0649 &quot;\u0643\u0648\u0631 <span dir=\"LTR\">COR388<\/span> &quot; \u0648\u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u062b\u0628\u0651\u0637 \u0642\u0648\u064a \u0644\u0625\u0646\u0632\u064a\u0645 \u062c\u064a\u0646\u062c\u064a\u0628\u0627\u0646\u0632\u060c \u0648\u0625\u0636\u0627\u0641\u0629 \u0644\u0630\u0644\u0643 \u064a\u0642\u0644\u0644 \u0628\u0635\u0648\u0631\u0629 \u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0648\u062c\u0648\u062f \u062a\u0644\u0643 \u0627\u0644\u0628\u0643\u062a\u0631\u064a\u0627 \u0648\u0647\u064a \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0645\u0631\u0636 \u0627\u0644\u0644\u062b\u0629 \u0641\u064a \u0623\u0645\u062e\u0627\u062e \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u0629\u060c \u0628\u0645\u0627 \u062e\u0641\u0636\u0651 \u0627\u0644\u0625\u0636\u0631\u0627\u0631 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u062e\u060c \u0643\u0645\u0627 \u0623\u0648\u0642\u0641 \u0623\u064a\u0636\u0627\u064b \u0645\u0631\u0643\u0628 &quot;\u0643\u0648\u0631&quot; \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0628\u064a\u062a\u0627 \u0623\u0645\u064a\u0644\u0648\u064a\u062f \u0627\u0644\u0633\u0627\u0645\u0629\u060c \u0645\u0645\u0627 \u064a\u0624\u0643\u062f \u0639\u0644\u0649 \u062f\u0648\u0631\u0647 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062e \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0648\u062e\u0627\u0635\u0629 \u062e\u0644\u0627\u064a\u0627 &quot;\u0642\u0631\u0646 \u0623\u0645\u0648\u0646 \u0623\u0648 \u0647\u064a\u0628\u0648\u0643\u0627\u0645\u0628\u0633 &quot;<span dir=\"LTR\">hippocampus<\/span> &quot; \u0628\u0627\u0644\u0645\u062e \u0648\u0647\u064a \u0645\u0646\u0637\u0642\u0629 \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u0630\u0627\u0643\u0631\u0629 \u0641\u064a \u0627\u0644\u0645\u062e.<\/p>\n<p dir=\"RTL\" style=\"text-align: justify;\"><span style=\"color:#d89e30;\">\u0627\u0644\u0645\u0631\u062c\u0639<\/span><\/p>\n<ul dir=\"ltr\">\n<li>Stephen S. Dominy, et al. (2019); <strong><a href=\"http:\/\/advances.sciencemag.org\/content\/5\/1\/eaau3333\">Porphyromonas gingivalis in Alzheimer&rsquo;s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors<\/a><\/strong><strong>.<\/strong> Science Advances&nbsp; 23 Jan 2019<span dir=\"RTL\">:<\/span>Vol. 5, no. 1, eaau3333&nbsp; DOI: 10.1126\/sciadv.aau3333<\/li>\n<\/ul>\n<p dir=\"ltr\">&nbsp;<\/p>\n<p><span style=\"color:#d89e30;\">\u0627\u0644\u0628\u0631\u064a\u062f \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0644\u0644\u0643\u0627\u062a\u0628:<\/span> <a href=\"mailto:redataha962@gmail.com\">redataha962@gmail.com<\/a><\/p>\n","protected":false},"featured_media":0,"menu_order":1048,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[13132,11230,11289],"class_list":["post-15553","articles","type-articles","status-publish","hentry","tag-13132","tag-11230","tag-11289"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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