{"id":15533,"date":"2019-01-28T11:19:36","date_gmt":"2019-01-28T11:19:36","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-1318\/"},"modified":"2019-01-28T11:19:36","modified_gmt":"2019-01-28T11:19:36","slug":"article-detail-1318","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-15533\/","title":{"rendered":"\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a \u0648\u0623\u062b\u0631\u0647\u0627 \u0639\u0644\u0649 \u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646"},"content":{"rendered":"

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\u0631\u0643\u0632 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0639\u0644\u0649 \u062e\u0644\u0644 \u0641\u064a \u0627\u0644\u062a\u0641\u0627\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0623\u0644\u0641\u0627 \u0633\u064a\u0646\u064a\u0648\u0643\u0644\u064a\u0646 (α-synuclein<\/span>) \u0645\u0643\u0648\u0646\u0627\u064b \u062a\u0643\u062a\u0644\u0627\u062a \u062a\u0633\u0628\u0628 \u062e\u0644\u0644\u0627\u064b \u0644\u0644\u0646\u0648\u0627\u0642\u0644 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0639\u0648\u064a \u0648\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u062d\u0627\u062f\u0629 \u062a\u0635\u0644 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a \u0646\u062a\u064a\u062c\u0629 \u062a\u0641\u0627\u0639\u0644\u0647\u0627 \u0645\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0628\u0642\u064a\u0629 \u0627\u0644\u062a\u064a \u0628\u062f\u0648\u0631\u0647\u0627 \u0623\u064a\u0636\u0627\u064b \u062a\u0632\u064a\u062f \u0645\u0646 \u062d\u062f\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0645\u0633\u0628\u0628\u0629 \u062a\u0642\u062f\u0645 \u0627\u0644\u0645\u0631\u0636 (2,3,5,6). \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0644\u0646\u0634\u0623\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0647 \u0645\u0639\u0642\u062f\u0629 \u0644\u0643\u0646 \u0627\u0646\u062a\u0642\u0627\u0644\u0647 \u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0639\u0631\u0648\u0641\u0627\u060c \u0641\u0628\u062d\u0633\u0628 \u0641\u0631\u0636\u064a\u0629 \u0647\u064a\u0643\u0648 \u0628\u0631\u0627\u0643 \u0639\u0627\u0644\u0645 \u0627\u0644\u062a\u0634\u0631\u064a\u062d \u0627\u0644\u0639\u0635\u0628\u064a \u0628\u062c\u0627\u0645\u0639\u0629 \u0623\u0648\u0644\u0645 \u0641\u064a \u0623\u0644\u0645\u0627\u0646\u064a\u0627 \u0641\u0625\u0646 \u062a\u0631\u0627\u0643\u0645 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0628\u062f\u0623 \u0645\u0646 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0639\u0648\u064a \u062b\u0645 \u064a\u0646\u062a\u0642\u0644 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0639\u0635\u0628 \u0627\u0644\u0645\u0628\u0647\u0645 (vagus nerve) \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a \u0645\u0633\u0628\u0628\u0627 \u0627\u0644\u0645\u0631\u0636 (2,3,5,7). \u0647\u0630\u0647 \u0627\u0644\u0641\u0631\u0636\u064a\u0629 \u062a\u0633\u062a\u0646\u062f \u0639\u0644\u0649 \u0645\u0644\u0627\u062d\u0638\u062a\u0647 \u0628\u0627\u0644\u062a\u0639\u0627\u0648\u0646 \u0645\u0639 \u0632\u0645\u0644\u0627\u0626\u0647 \u0644\u0623\u062c\u0633\u0627\u0645 \u0644\u0648\u0631\u064a (\u0627\u0648 \u062a\u0643\u062a\u0644\u0627\u062a \u0627\u0644\u0623\u0644\u0641\u0627 \u0633\u064e\u064a\u0646\u064a\u0648\u0643\u0644\u064a\u0646) \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u062a\u0648\u0641\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0645\u0631\u0636(7). \u0643\u0645\u0627 \u062a\u0633\u062a\u0646\u062f \u0627\u064a\u0636\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629 \u0644\u0644\u0642\u0648\u0627\u0631\u0636 \u0627\u0644\u062a\u064a \u0631\u0635\u062f\u062a \u0645\u0639\u062f\u0644\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0639\u0635\u0628 \u0627\u0644\u0645\u0628\u0647\u0645 \u0628\u0639\u062f \u062d\u0642\u0646\u0647\u0627 \u0628\u062c\u062f\u0627\u0631 \u0627\u0644\u0645\u0639\u062f\u0629 (5)\u060c \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u0627\u0645 \u0628\u0647\u0627 \u0633\u0641\u0646\u0633\u0648\u0646 (Svensson<\/span>) \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0645\u0641\u0627\u062f\u0647\u0627 \u0623\u0646 \u0645\u0646 \u062a\u0639\u0631\u0636\u0648\u0627 \u0644\u0639\u0645\u0644\u064a\u0629 \u062c\u0631\u0627\u062d\u064a\u0629 \u0633\u0627\u0628\u0642\u0627\u064b \u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u062c\u0632\u0626\u064a \u0623\u0648 \u0643\u0644\u064a \u0644\u0644\u0639\u0635\u0628 \u062a\u0642\u0644 \u0644\u062f\u064a\u0647\u0645 \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0622\u062e\u0631\u064a\u0646 (4).<\/p>\n

\u0627\u0630\u0627\u064b\u060c \u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u062a\u0631\u0627\u0643\u0645 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u061f<\/strong> \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0623\u0644\u0641\u0627 \u0633\u064a\u0646\u064a\u0648\u0643\u0644\u064a\u0646 \u0641\u064a \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u062f\u0648\u0631 \u0641\u064a \u0645\u062d\u0627\u0631\u0628\u0629 \u0627\u0644\u0645\u0633\u0628\u0628\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0643\u0645\u0627 \u062a\u0634\u064a\u0631 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0628\u062c\u0627\u0645\u0639\u0629 \u062c\u0648\u0631\u062c \u062a\u0627\u0648\u0646 \u0645\u0627\u064a\u0643\u0644 \u0632\u0627\u0633\u0644\u0648\u0641 \u0648\u0632\u0645\u0644\u0627\u0626\u0647 \u0628\u0625\u064a\u062c\u0627\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0639\u062f\u0648\u0649 \u0646\u0648\u0631\u0648\u0641\u064a\u0631\u0648\u0633 (norovirus<\/span>: \u0641\u064a\u0631\u0648\u0633 \u064a\u0633\u0628\u0628 \u0627\u0644\u062a\u0647\u0627\u0628 \u0645\u0639\u062f\u064a \u0648\u0645\u0639\u0648\u064a) \u0648\u062a\u0646\u0634\u064a\u0637\u0647\u0627 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0644\u0645\u0646\u0627\u0639\u064a\u0629. \u0643\u0645\u0627 \u062a\u0642\u062a\u0631\u062d \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u0644\u0639\u0627\u0644\u0650\u0645 \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0628\u062c\u0627\u0645\u0639\u0629 \u0644\u0648\u064a\u0633\u0641\u064a\u0644 \u0631\u0648\u0628\u0631\u062a \u0641\u0631\u064a\u062f\u0644\u0627\u0646\u062f \u0623\u0646 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u062a\u0646\u062a\u062c \u0623\u0644\u064a\u0627\u0641 \u0628\u0631\u0648\u062a\u064a\u0646\u064a\u0629 \u0635\u0644\u0628\u0629 \u062a\u0644\u062a\u0641 \u062d\u0648\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062c\u0627\u0648\u0631\u0629 \u0644\u0647\u0627 \u0628\u0634\u0643\u0644 \u062e\u0627\u0637\u0626 \u0628\u0637\u0631\u064a\u0642\u0629 \u062a\u0634\u0628\u0647 \u0627\u0644\u0628\u0631\u064a\u0648\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0645\u0631\u0636 \u062c\u0646\u0648\u0646 \u0627\u0644\u0628\u0642\u0631 (7).<\/p>\n

\u0647\u0646\u0627\u0643 \u0637\u0631\u064a\u0642\u0629 \u0623\u062e\u0631\u0649 \u0639\u062f\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0644\u0646\u0634\u0623\u0629 \u0627\u0644\u0645\u0631\u0636 \u0627\u0642\u062a\u0631\u062d\u0647\u0627 \u0639\u0627\u0644\u0645 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0628\u0645\u0639\u0647\u062f \u0643\u0627\u0644\u064a\u0641\u0648\u0631\u0646\u064a\u0627 \u0644\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0633\u0627\u0631\u0643\u064a\u0633 \u0645\u0627\u0632\u0645\u0627\u0646\u064a\u0627\u0646 \u0645\u0641\u0627\u062f\u0647\u0627 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0642\u0635\u064a\u0631\u0629 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 (SCFA‘s<\/span>) \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0639\u0645\u0644\u064a\u0627\u062a \u0647\u0636\u0645 \u0648\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0644\u0644\u0623\u0637\u0639\u0645\u0629 \u0642\u062f \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0628\u0642\u064a\u0629 \u0627\u0644\u0635\u063a\u064a\u0631\u0629. \u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u062f \u062a\u0646\u062a\u0642\u0644 \u0625\u0645\u0627 \u0639\u0628\u0631 \u0627\u0644\u0639\u0635\u0628 \u0627\u0644\u0645\u0628\u0647\u0645 \u0623\u0648 \u0628\u0637\u0631\u0642 \u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0645\u062c\u0631\u0649 \u0627\u0644\u062f\u0645 (2,5,6,7). \u0644\u0643\u0646 \u0627\u0644\u0623\u0645\u0631 \u0645\u0627\u0632\u0627\u0644 \u0641\u064a \u0628\u062f\u0627\u064a\u062a\u0647.<\/p>\n

\u0627\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062d\u0627\u0644\u064a \u0644\u0644\u0645\u0631\u0636 \u064a\u0647\u062f\u0641 \u0644\u062a\u0628\u0637\u064a\u0621 \u062a\u0637\u0648\u0631\u0647 \u0648\u062a\u062e\u0641\u064a\u0641 \u062d\u062f\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636. \u0648\u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u064a\u0643\u0648\u0646 \u0628\u0639\u062f \u0638\u0647\u0648\u0631 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062d\u0631\u0643\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0643\u0648\u0646 \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0642\u062f \u062a\u0636\u0631\u0631\u062a \u062d\u064a\u0646\u0647\u0627 (5).<\/p>\n

\u0645\u0627 \u064a\u0632\u0627\u0644 \u0627\u0644\u0645\u0648\u0636\u0648\u0639 \u0642\u064a\u062f \u0627\u0644\u0628\u062d\u062b \u0648\u0644\u0643\u0646\u0647 \u0642\u062f \u064a\u0641\u062a\u062d \u0644\u0646\u0627 \u0623\u0628\u0648\u0627\u0628\u0627\u064b \u0644\u0627\u0628\u062a\u0643\u0627\u0631 \u0637\u0631\u0642\u0627\u064b \u062c\u062f\u064a\u062f\u0629 \u0644\u0641\u062d\u0635 \u0627\u0644\u0645\u0631\u0636 \u0648\u0639\u0644\u0627\u062c\u0647. \u0645\u062b\u0644 \u0627\u0644\u0634\u0631\u0643\u0629 \u0627\u0646\u062a\u0631\u064a\u0646 \u0627\u0644\u062a\u064a \u0645\u0627\u062a\u0632\u0627\u0644 \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0631\u0643\u0628 \u062c\u062f\u064a\u062f \u064a\u0639\u0645\u0644 \u0644\u062a\u0628\u0637\u064a\u0626 \u062a\u0643\u062a\u0644\u0627\u062a \u0627\u0644\u0623\u0644\u0641\u0627 \u0633\u064e\u064a\u0646\u064a\u0648\u0643\u0644\u064a\u0646 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0628\u0647\u062f\u0641 \u062a\u0642\u0644\u064a\u0644 \u062d\u062f\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0648\u0622\u0645\u0644\u064a\u0646 \u0627\u064a\u0636\u0627\u064b \u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0623\u0633\u0628\u0627\u0628 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0644\u0645\u0631\u0636 \u0644\u0639\u0644\u0627\u062c\u0647\u0627 \u0623\u0648 \u0645\u0646\u0639\u0647\u0627 (7).<\/p>\n

\u0627\u0644\u0634\u0643\u0644 1: \u0637\u0631\u064a\u0642\u0629 \u0645\u0628\u0633\u0637\u0629 \u062a\u0634\u0631\u062d \u062f\u0648\u0631 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0628\u0645\u0631\u0636 \u0627\u0644\u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646<\/span><\/p>\n

\"\"<\/p>\n

\n\u0627\u0644\u0645\u0631\u0627\u062c\u0639<\/span><\/p>\n

    \n
  1. Gut\/brain axis and the microbiota<\/a>
    \n\t– By<\/span>:  Mayer, Emeran A.; <\/span>Tillisch, Kirsten; Gupta, Arpana<\/span>
    \n\t– JOURNAL OF CLINICAL INVESTIGATION
    \n\t– Volume: 125   <\/span>Issue: 3   <\/span>Pages: 926-938   <\/span>Published: MAR 2015<\/span>
    \n\t <\/li>\n
  2. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease<\/a>
    \n\t– By<\/span>:  Sampson, Timothy R.; Debelius, Justine <\/span>W.; <\/span>Thron, Taren;
    \n\t et al<\/span>CELL
    \n\t– Volume: 167   <\/span>Issue: 6   <\/span>Pages: 1469-+   <\/span>Published: DEC 1 2016<\/span>
    \n\t <\/li>\n
  3. Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases<\/a>
    \n\t– By <\/span>: Ghaisas, Shivani; <\/span>Maher, Joshua; Kanthasamy, <\/span>Anumantha
    \n\t– PHARMACOLOGY & <\/span>THERAPEUTICS
    \n\t– Volume: 158   Pages: 52-62   <\/span>Published: FEB       2016<\/span>
    \n\t <\/li>\n
  4. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration<\/a>
    \n\t– By: Dinan <\/span>Timothy G.; Cryan, <\/span>John F.<\/span>
    \n\t– JOURNAL OF PHYSIOLOGY-<\/span>LONDON
    \n\t– Volume: 595   <\/span>Issue: 2   <\/span>Pages: 489-503   <\/span>Published : JAN 2017<\/span>
    \n\t <\/li>\n
  5. Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease<\/a>
    \n\t–By <\/span>: Troncoso–<\/span>Escudero, Paulina; <\/span>Parra, Alejandra; Nassif, Melissa;
    \n\tet al.<\/span> FRONTIERS IN NEUROLOGY 
    \n\t–<\/span> Volume: 9     <\/span>Article Number: 860   <\/span>Published: OCT 15 2018<\/span>
    \n\t <\/li>\n
  6. The Central Nervous System and the Gut Microbiome<\/a>
    \n\t– By <\/span>: Sharon, Gil; <\/span>Sampson, Timothy R.; <\/span>Geschwind, Daniel H.;
    \n\t et al.<\/span> CELL
    \n\t– Volume: 167   <\/span>Issue: 4   <\/span>Pages: 915-932   <\/span>Published: NOV 3 2016<\/span>
    \n\t <\/li>\n
  7. Does Parkinson’s Begin in the Gut?<\/a>
    \n\t– By <\/span>: Kwon D, <\/span>Scientific American  Published May  8 2018 <\/span><\/li>\n<\/ol>\n

     <\/p>\n

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