{"id":14919,"date":"2017-08-17T20:25:42","date_gmt":"2017-08-17T20:25:42","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-540\/"},"modified":"2017-08-17T20:25:42","modified_gmt":"2017-08-17T20:25:42","slug":"article-detail-540","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-14919\/","title":{"rendered":"\u0641\u064a \u0630\u0643\u0631\u0649 \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0644\u0644\u0633\u0631\u0637\u0627\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color:#008080;\">\u0627\u0644\u0631\u0627\u0628\u0639 \u0645\u0646 \u0641\u0628\u0631\u0627\u064a\u0631 \u0643\u0644 \u0639\u0627\u0645 \u062a\u062d\u064a\u064a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0648\u0627\u0644\u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u0644\u0628\u062d\u0648\u062b 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\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 . \u0648\u0647\u0630\u0647 \u0627\u0644\u062d\u0648\u0627\u062c\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 ( \u0646\u0642\u0627\u0637 \u0627\u0644\u062a\u0641\u062a\u064a\u0634 \u0648\u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629) \u0645\u062a\u0633\u0642\u0628\u0644\u0627\u062a CTLA-4&nbsp; \u0648 PD-1\/ PD-L1.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0639\u0642\u0627\u0642\u064a\u0631 \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0628\u0631\u0648\u062a\u064a\u0646 CTLA-4 Cytotoxic T Lymphocyte associated antigen 4:<\/span> CTLA-4 \u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0645\u0649 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0628\u0631 \u0623\u0639\u0644\u0649 \u0631\u062a\u0628\u0629 \u0644\u0628\u062f\u0621 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648\u062a\u0643\u0645\u0646 \u0648\u0638\u064a\u0641\u0629 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0643\u0641\u0631\u0645\u0644\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0644\u0645\u0646\u0639\u0647\u0627 \u0645\u0646 \u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0644\u064a\u0645\u0629 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\u0628\u0627\u0646\u062a\u0627\u062c \u0639\u0642\u0627\u0631\u0627\u062a \u062a\u0633\u062a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0644\u062a\u0645\u0643\u0646 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0645\u0646 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u062f\u0648\u0631\u0647 \u0641\u064a \u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0642\u0636\u0627\u0621 \u0639\u0644\u064a\u0647\u0627\u060c \u0648\u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631:<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0639\u0642\u0627\u0631 Ipilimumab (Yervoy&reg;<\/span><\/p>\n<p style=\"text-align: justify;\">\u0639\u0642\u0627\u0631 \u0627\u0628\u064a\u0644\u064a\u0645\u0648\u0645\u0627\u0628 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u0636\u0627\u062f \u0648\u062d\u064a\u062f \u064a\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 CTLA-4 \u0627\u0644\u0645\u062b\u0628\u0637 \u0648\u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u064a\u0645\u0646\u0639\u0647\u0627 \u0645\u0646 \u0627\u0644\u0639\u0645\u0644 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u062d\u0641\u0632 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0636\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0628\u0627\u0644\u062c\u0633\u0645 . \u0648\u0642\u062f \u0623\u062e\u0630 \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 FDA&nbsp; \u0641\u064a 25\/3\/2011&nbsp; \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f\u064a \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0635\u064a\u0628 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u063a\u064a\u0629.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(218, 165, 32);\">\u0637\u0631\u064a\u0642\u0629 \u0639\u0645\u0644 \u0639\u0644\u0627\u062c<\/span><span style=\"color: rgb(218, 165, 32);\">&nbsp;\u0627\u0628\u064a\u0644\u064a\u0645\u0648\u0645\u0627\u0628<\/span><\/p>\n<p style=\"text-align: justify;\">\u064a\u0635\u0639\u0628 \u0639\u0644\u0627\u062c\u0647 \u0628\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062c\u0631\u0627\u062d\u064a\u0629 \u062d\u064a\u062b \u0644\u0647\u0627 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631&nbsp;\u0643\u0645\u0627 \u0627\u0646\u0647 \u0628\u062f\u0623 \u062d\u0642\u0628\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0636\u062f \u0623\u0646\u0648\u0627\u0639 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 . \u0648\u0644\u0643\u0646 \u0645\u0646 \u0639\u064a\u0648\u0628 \u0647\u0630\u0627 \u0627\u0644\u0639\u0642\u0627\u0631 \u0623\u0646\u0647 \u064a\u0633\u0645\u062d \u0644\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 .&nbsp;\u0644\u0630\u0627\u060c \u0628\u062f\u0621 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0628\u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u062f\u0648\u0627\u0621 \u0622\u062e\u0631 \u0623\u0643\u062b\u0631 \u062a\u062e\u0635\u0635\u064a\u0629. \u0648\u0645\u0646 \u0647\u0646\u0627 \u0628\u062f\u0623\u062a \u062d\u0642\u0628\u0629&nbsp;\u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631&nbsp;\u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0646\u0648\u0639 \u0622\u062e\u0631 \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0645\u062b\u0628\u0637\u0629 PD-1\/PDL1.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0647 \u0644 PD-1 or PDL-1<\/span><\/p>\n<p style=\"text-align: justify;\">PD-1 \u0647\u0648&nbsp;\u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u0648\u0638\u064a\u0641\u062a\u0647 \u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0644\u0627 \u062a\u0648\u062c\u062f \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u0631\u064a\u0628\u0629 \u0639\u0646\u062f\u0645\u0627 \u062a\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0645\u0646\u0627\u0638\u0631 \u0644\u0647\u0627 PD-L1 \u0648\u0644\u0643\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u062a\u0645\u062a\u0644\u0643 PD-L1 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0645\u0646\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0645\u0646 \u0645\u0647\u0627\u062c\u0645\u062a\u0647. \u0648\u0628\u0639\u062f \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0628\u0634\u0631\u0629 \u0644\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0645\u062b\u0628\u0637 CTLA- \u0628\u062f\u0623\u062a \u0623\u0646\u0638\u0627\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0628\u062d\u0645\u0627\u0633 \u0634\u062f\u064a\u062f \u062a\u062c\u0627\u0647 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0622\u062e\u0631 PD-1\/ PD-L1. PD-1&nbsp; \u0647\u0648 \u0623\u062d\u062f \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0646\u0634\u0637\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u062b\u0628\u0637 \u0646\u0634\u0627\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0639\u0646\u062f\u0645\u0627 \u062a\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0645\u0646\u0627\u0638\u0631 \u0644\u0647\u0627 PD-1 ligand . \u0648\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u0645\u0646\u0647\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0635\u064a\u0628 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u063a\u064a\u0629 \u0628\u0627\u0644\u062c\u0644\u062f \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0631\u0626\u0629 \u064a\u0648\u062c\u062f \u0639\u0644\u0649 \u0633\u0637\u062d\u0647\u0627 PD-1 ligand \u0648\u0627\u0644\u0630\u064a \u0644\u0647 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 PD-1 \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u062b\u0628\u0637 \u0646\u0634\u0627\u0637\u0647\u0627 \u0648\u064a\u0645\u0646\u0639 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648\u0645\u0647\u0627\u062c\u0645\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0644\u0647\u0627 . \u0648\u0642\u062f \u0627\u0633\u062a\u0641\u0627\u062f \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0645\u0646 \u0641\u0647\u0645 \u062a\u0644\u0643 \u0627\u0644\u062e\u062f\u0639\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062e\u062f\u0645\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0644\u0644\u0647\u0631\u0648\u0628 \u0645\u0646 \u0627\u0644\u062c\u064a\u0634 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0648\u0628\u062f\u0623\u0648\u0627 \u0628\u0625\u0646\u062a\u0627\u062c \u0639\u0642\u0627\u0642\u064a\u0631 \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0647\u0627 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0645\u062b\u0628\u0637 PD-1. \u0645\u0646 \u0647\u0646\u0627 \u0644\u0645 \u062a\u0639\u062f \u0647\u0646\u0627\u0643 \u0641\u0631\u0635\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0644\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0647 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u064a\u062a\u0645 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062c\u064a\u0634 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629. \u0648\u0645\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0644\u064a\u0649 \u0645\u0631\u0636\u0649 \u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f\u064a \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0623\u0639\u0637\u062a \u0646\u062a\u0627\u0626\u062c \u0645\u0628\u0634\u0631\u0629 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0627\u062a\u062c\u0627\u0647. \u0648\u0633\u0646\u0633\u0631\u062f \u0628\u0639\u0636\u0627\u064b \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0648\u0627\u0644\u062a\u064a \u0623\u062e\u0630\u062a \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u062d\u062f\u064a\u062b\u0627 \u0644\u064a\u0637\u0631\u062d \u0641\u064a \u0627\u0644\u0623\u0633\u0648\u0627\u0642 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0644\u0628\u062f\u0621 \u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u0645\u0646\u0630 \u0630\u0644\u0643 \u0642\u0627\u0645\u062a \u0627\u0644\u0634\u0631\u0643\u0627\u062a \u0628\u0625\u0646\u062a\u0627\u062c \u0645\u0636\u0627\u062f\u0627\u062a \u0644\u0647\u0627 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628PD-1 &amp; PD-L1 \u0648\u0645\u0646\u0647\u0627 \u062a\u0646\u0642\u0633\u0645 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0625\u0644\u0649 :<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0639\u0642\u0627\u0642\u064a\u0631 \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 PD-1&nbsp; \u0648\u062a\u0634\u0645\u0644 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0627\u062a\u064a\u0629<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\">\u0639\u0642\u0627\u0631 (Nivolumab, Bristol-Myers Squibb )<\/li>\n<li style=\"text-align: justify;\">\u0639\u0642\u0627\u0631 Pembrolizumab, Merck, Whitehouse Station, NJ<\/li>\n<li style=\"text-align: justify;\">\u0639\u0642\u0627\u0631 Pidilizumab, CureTech, Yavne, Israel)<\/li>\n<li style=\"text-align: justify;\">\u0639\u0642\u0627\u0642\u064a\u0631 \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0645\u0646\u0627\u0638\u0631 PD-L1 \u0648\u062a\u0634\u0645\u0644 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0627\u062a\u064a\u0629:<\/li>\n<li style=\"text-align: justify;\">(MPDL3280A, Genentech, South San Francisco, CA<\/li>\n<li style=\"text-align: justify;\">MEDI4736\/ MedImmune\/AstraZeneca<\/li>\n<li style=\"text-align: justify;\">BMS-936559, Bristol-Myers Squib<\/li>\n<li style=\"text-align: justify;\">MSB0010718C, EMD Serono, Rockland, MA<\/li>\n<li style=\"text-align: justify;\">\u0639\u0642\u0627\u0642\u064a\u0631 \u062a\u062b\u0628\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0648\u062c\u062f \u0639\u0644\u064a\u0647\u0627 PD-1(deplete PD-1&ndash;positive T cells)<\/li>\n<li style=\"text-align: justify;\">AMP-224 (Amplimmune, Gaithersburg, MD\/GlaxoSmithKline<\/li>\n<li style=\"text-align: justify;\">Philadelphia, PA<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u0648\u0633\u0648\u0641 \u0646\u0634\u064a\u0631&nbsp; \u0625\u0644\u0649 \u062f\u0648\u0627\u0626\u064a\u0646 \u0623\u062b\u0628\u062a\u0627 \u0646\u062a\u0627\u0626\u062c\u0647\u0645\u0627 \u0627\u0644\u0641\u0639\u0651\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u0639 \u0648\u062c\u0648\u062f \u0623\u0642\u0644 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f\u064a \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0635\u064a\u0628 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0628\u063a\u064a\u0629 \u0628\u0627\u0644\u062c\u0644\u062f \u0648\u0643\u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0644\u064a\u0629 . \u062d\u064a\u062b \u0623\u0639\u0637\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0628\u062f\u0626\u064a\u0629 \u062a\u062c\u0627\u0647 \u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c&nbsp; \u0628\u0646\u0633\u0628\u0629 32% \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0648\u064a(dacarbazine or carboplatin\/paclitaxel ) \u0628\u0646\u0633\u0628\u0629 11% \u060c \u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0645\u0646\u0641\u0635\u0644\u0629 \u0644\u0639\u0644\u0627\u062c nivolumab \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u0645\u064a\u0627\u0648\u064a dacarbazine \u0623\u062b\u0628\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0641\u0627\u0626\u0642\u0629 \u0639\u0644\u0649 \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u064a.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0645\u0646\u0627\u0638\u0631&nbsp; PD-L1&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">&nbsp;\u0639\u0642\u0627\u0631 \u0627\u0644\u0646\u064a\u0641\u0644\u0648\u0645\u0627\u0628 Opdivo<\/span><\/p>\n<p style=\"text-align: justify;\">\u064a\u0628\u062f\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u0633\u0645\u0649 \u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628&nbsp; \u0623\u0643\u062b\u0631 \u0646\u0634\u0627\u0637\u0627\u064b \u0648\u0623\u0645\u0627\u0646\u0627\u064b \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0648\u0627\u0644\u0630\u064a \u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646&nbsp;\u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f \u0627\u0644\u0645\u062a\u0642\u062f\u0645. \u0648\u0642\u062f\u0645\u062a \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u062c\u0645\u0639\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0644\u0637\u0628 \u0639\u0644\u0645 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 (ESMO) \u0641\u064a 26-30 \u0633\u0628\u062a\u0645\u0628\u0631&nbsp;\u0641\u064a \u0645\u062f\u0631\u064a\u062f\u060c \u0623\u0633\u0628\u0627\u0646\u064a\u0627. \u0641\u064a \u0643\u0644 \u0639\u0627\u0645 \u062c\u062f\u064a\u062f \u064a\u0645\u0631 \u0639\u0644\u064a\u0646\u0627 \u0647\u0646\u0627\u0643 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646&nbsp;\u0623\u0643\u062b\u0631 \u0645\u0646 \u0645\u0644\u064a\u0648\u0646 \u062d\u0627\u0644\u0629 \u0625\u0635\u0627\u0628\u0629 \u062c\u062f\u064a\u062f\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f \u0628\u0634\u0643\u0644 \u0639\u0627\u0645\u060c \u0645\u0646\u0647\u0627 \u0645\u0627&nbsp;\u064a\u0642\u0631\u0628 \u0645\u0646 68 \u0623\u0644\u0641 \u062d\u0627\u0644\u0629 \u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u0648\u0627\u0644\u0630\u064a 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\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u062f\u064a\u062f \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0644\u0648\u0643\u064a\u0645\u064a\u0627 \u0648\u0627\u0644\u064a\u0645\u0641\u0648\u0645\u0627\u060c \u0648\u0643\u0627\u0646\u062a \u0647\u0646\u0627\u0643 \u0645\u062e\u0627\u0648\u0641 \u0628\u0634\u0627\u0646 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u0635\u0639\u0648\u0628\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0648\u0627\u062c\u0629 \u0635\u0646\u0627\u0639\u0629 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u062f\u064a\u062f \u0628\u0634\u0643\u0644 \u064a\u062a\u0633\u0639 \u0644\u064a\u0634\u0645\u0644 \u0645\u0631\u0636\u0649 \u0645\u0646&nbsp;\u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0648\u0644\u0643\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u062e\u0627\u0648\u0641 \u0643\u0627\u0646\u062a \u0645\u0646 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\u0627\u0644\u0645\u0646\u0627\u0639\u064a&nbsp; CAR-T&nbsp; \u0639\u0644\u0649 \u0645\u062f\u0649 \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u062b\u0644\u0627\u062a \u0627\u0644\u0645\u0627\u0636\u064a\u0629 \u0648\u0642\u0627\u0645\u0648\u0627 \u0628\u0627\u0633\u062a\u062b\u0645\u0627\u0631 \u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u062f\u0648\u0644\u0627\u0631\u0627\u062a \u0644\u062a\u0637\u0648\u064a\u0631 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0627\u0644\u062e\u0644\u0627\u0635\u0629<\/span><\/p>\n<p style=\"text-align: justify;\">\u0642\u062f\u0645\u0646\u0627 \u0647\u0646\u0627 \u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u062d\u0627\u0644\u064a\u0627 \u0641\u064a \u0623\u0645\u0631\u064a\u0643\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0648\u0631\u0627\u0645. \u0648\u0645\u0627 \u0646\u062a\u0645\u0646\u0627\u0647 \u0647\u0648&nbsp;\u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a&nbsp; \u0644\u062e\u062f\u0645\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0641\u064a \u0623\u0648\u0637\u0627\u0646\u0646\u0627.<\/p>\n<p style=\"text-align: center;\"><span style=\"color:#008080;\">\u0645\u0639 \u062a\u0645\u0646\u064a\u0627\u062a\u0646\u0627 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u0627\u0644\u0634\u0641\u0627\u0621<\/span><\/p>\n<p style=\"text-align: center;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"color:#DAA520;\">\u0627\u0644\u0628\u0631\u064a\u062f \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a 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