{"id":14655,"date":"2017-05-27T15:51:57","date_gmt":"2017-05-27T15:51:57","guid":{"rendered":"https:\/\/arsco.org\/articles\/article-detail-99\/"},"modified":"2024-09-10T10:08:20","modified_gmt":"2024-09-10T07:08:20","slug":"article-detail-99","status":"publish","type":"articles","link":"https:\/\/arsco.org\/en\/articles\/article-detail-14655\/","title":{"rendered":"\u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u064a\u064f\u063a\u064a\u0651\u0640\u0631 \u0645\u0650\u0646 \u062c\u064a\u0646\u0627\u062a\u0650\u0643 \u0648\u064a\u064f\u0636\u0627\u0639\u0641 \u0645\u0650\u0646 \u0645\u062e\u0627\u0637\u0631 \u062d\u062f\u0648\u062b \u0633\u0631\u0637\u0627\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #008080;\">\u0645\u0627 \u064a\u062a\u0631\u0643\u0647 \u0627\u0644\u0622\u0628\u0627\u0621 \u0645\u0646 \u0645\u064a\u0631\u0627\u062b\u064d \u062c\u064a\u0646\u064a\u0651 \u0644\u0623\u0628\u0646\u0627\u0626\u0647\u0645 \u0641\u064a \u0635\u0648\u0631\u0629 \u0635\u0641\u0627\u062a \u0648\u0631\u0627\u062b\u064a\u0629\u060c \u064a\u064f\u063a\u064a\u0651\u0650\u0631\u064f\u0647 \u062a\u062f\u062e\u064a\u0646 \u0627\u0644\u0633\u062c\u0627\u0626\u0631 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u0627 \u064a\u064f\u0640\u062d\u062f\u062b\u0647 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a-\u062a\u062d\u0648\u0631\u0627\u062a mutations \u063a\u064a\u0631 \u0645\u0631\u063a\u0648\u0628\u0629- \u0641\u064a \u0645\u0627 \u062a\u062d\u062a\u0648\u064a\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u0646 \u062d\u0627\u0645\u0636 \u0646\u0648\u0648\u064a &#8220;\u062f\u064a \u0625\u0646 \u0625\u064a\u0647&#8221; 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\u064a\u0642\u0648\u0645 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u062a\u062b\u0628\u064a\u0637 \u062a\u0643\u0648\u0651\u064f\u0646\u0650 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 tumor suppressor gene\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0646\u0647 \u064a\u0642\u0648\u0645 \u0628\u0648\u0638\u0627\u0626\u0641\u064e \u0639\u062f\u064a\u062f\u0629 \u0623\u062e\u0631\u0649 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u0644\u0643 \u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0633\u0631\u0639\u0627\u0646 \u0645\u0627 \u062a\u062e\u062a\u0641\u064a \u0628\u0645\u062c\u0631\u062f \u062d\u062f\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646. \u0648 \u0641\u064a \u0630\u0627\u062a \u0627\u0644\u0645\u0648\u0636\u0648\u0639 \u0646\u0634\u0631\u062a \u0645\u062c\u0644\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 &#8220;\u0633\u0627\u064a\u0646\u0633 Science&#8221; \u062e\u0644\u0627\u0644 \u0647\u0630\u0627 \u0627\u0644\u0634\u0647\u0631 &#8220;\u0646\u0648\u0641\u0645\u0628\u0631 2016&#8221; \u062f\u0631\u0627\u0633\u0629 \u0627\u0634\u062a\u0631\u0643\u062a\u0652 \u0641\u064a\u0647\u0627 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062c\u0647\u0627\u062a \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0645\u0646 \u0628\u0639\u0636 \u0627\u0644\u062f\u0648\u0644 \u0645\u0646 \u0628\u064a\u0646\u0647\u0627 &#8220;Wellcome Trust Sanger Institute in Cambridgeshire and the Los Alamos National Laboratory in New Mexico&#8221;.<\/p>\n<p style=\"text-align: justify;\">\u0648\u0642\u062f \u0623\u0648\u0636\u062d\u062a\u0652 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0642\u0629 \u0645\u0628\u0627\u0634\u0631\u0629 \u0648\u0637\u0631\u062f\u064a\u0629 \u0628\u064a\u0646 \u0639\u062f\u062f \u0627\u0644\u0633\u062c\u0627\u0626\u0631 \u0627\u0644\u0630\u064a \u064a\u0642\u0648\u0645 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0628\u062a\u062f\u062e\u064a\u0646\u0647\u0627\u060c \u0648\u0639\u062f\u062f \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062b \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0628\u064a\u0646 \u0627\u0644\u0645\u062f\u062e\u0646\u064a\u0646\u060c \u0648\u0627\u0644\u062a\u064a \u0623\u0638\u0647\u0631\u062a\u0647\u0627 \u0627\u0644\u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062d\u062f\u062b\u062a\u0652 \u0641\u064a \u062a\u0631\u062a\u064a\u0628 \u0627\u0644\u0642\u0648\u0627\u0639\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u0648\u062c\u064a\u0646\u064a\u0629 sequence \u0641\u064a &#8220;\u062f\u064a \u0625\u0646 \u0625\u064a\u0647&#8221; 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\u0648\u0627\u0644\u062a\u064a \u0628\u062f\u0648\u0631\u0647\u0627 \u062a\u062d\u0648\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0627\u062f\u064a\u0629 \u0625\u0644\u0649 \u0633\u0631\u0637\u0627\u0646\u064a\u0629\u060c \u062d\u064a\u062b \u0623\u0646 \u062f\u062e\u0627\u0646 \u0627\u0644\u0633\u062c\u0627\u0626\u0631 \u064a\u0639\u062c\u0644 \u0645\u0646 \u0633\u0631\u0639\u0629 \u0627\u0646\u0642\u0633\u0627\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0635\u0648\u0631\u0629 \u0643\u0628\u064a\u0631\u0629. \u0648 \u0623\u0648\u0636\u062d\u062a\u0652 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0643\u0630\u0644\u0643 \u0623\u0646\u0647 \u0628\u0627\u0644\u0625\u0645\u0643\u0627\u0646 \u0648\u0636\u0639 \u0625\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062b \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0628\u0633\u0628\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0643\u0634\u0641 \u0627\u0644\u0646\u0642\u0627\u0628 \u0639\u0646 \u0622\u0644\u064a\u0629 \u062a\u0637\u0648\u0631 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0641\u064a \u0645\u0631\u0627\u062d\u0644\u0647 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629\u060c \u0647\u0630\u0627 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0646\u0647 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u0645 \u062a\u0637\u0628\u064a\u0642 \u062a\u0644\u0643 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0639\u0644\u0649 \u0623\u0646\u0648\u0627\u0639 \u0623\u062e\u0631\u0649 \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u062e\u0627\u0635\u0629 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0633\u0645\u0646\u0629 obesity. \u064a\u064f\u0630\u0643\u0631 \u0623\u0646\u0647 \u0648\u0637\u0628\u0642\u0627\u064b \u0644\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629\u060c \u0641\u0625\u0646 \u062d\u0648\u0644\u064a\u0652 \u0633\u062a\u0629 \u0645\u0644\u0627\u064a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0628\u0634\u0631 \u064a\u0645\u0648\u062a\u0648\u0646 \u0633\u0646\u0648\u064a\u0627\u064b \u062c\u0631\u0627\u0621\u064e \u0623\u0645\u0631\u0627\u0636\u064d \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062a\u062f\u062e\u064a\u0646\u060c \u0648\u062d\u0633\u0628 \u0645\u0627 \u0630\u0643\u0631\u062a\u0647 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 &#8220;WHO &#8221; \u0641\u0625\u0646 \u0639\u062f\u062f \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0628\u0633\u0628\u0628 \u0627\u0644\u062a\u062f\u062e\u064a\u0646 \u062e\u0644\u0627\u0644 \u0647\u0630\u0627 \u0627\u0644\u0642\u0631\u0646 \u064a\u0642\u0627\u0631\u0628 \u0628\u0644\u064a\u0648\u0646-\u0645\u0644\u064a\u0627\u0631-\u0641\u0631\u062f \u0645\u0646 \u0627\u0644\u0628\u0634\u0631.<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #d89e30;\">\u0627\u0644\u0645\u0631\u0627\u062c\u0639:<\/span><\/p>\n<ul dir=\"ltr\">\n<li><a href=\"http:\/\/science.sciencemag.org\/content\/354\/6312\/618\">Mutational signatures associated with tobacco smoking in human cancer<\/a>;\u00a0 Ludmil B. Alexandrov et al ; Science\u00a0 04 Nov 2016: Vol. 354, Issue 6312, pp. 618-622. DOI: 10.1126\/science.aag0299<\/li>\n<li><a href=\"http:\/\/tobaccocontrol.bmj.com\/content\/early\/2016\/10\/31\/tobaccocontrol-2016-053087\">Public health benefits from pictorial health warnings on US cigarette packs<\/a>: a SimSmoke simulation; David T Levy, Darren Mays, Zhe Yuan, David Hammond, James F Thrasher; Tobacco Control, 2016; tobaccocontrol-2016-053087. DOI: 10.1136\/tobaccocontrol-2016-053087; Published Online 2 November 2016<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4637815\/\">The genome as a record of environmental exposure<\/a>; S. Nik-Zainal et al., Mutagenesis. 2015 Nov; 30(6): 763\u2013770.<\/li>\n<li><a href=\"http:\/\/perspectivesinmedicine.cshlp.org\/content\/early\/2016\/08\/06\/cshperspect.a026179.abstract\">Somatic TP53 Mutations in the Era of Genome Sequencing<\/a>; P. Hainaut, G. P. Pfeifer, Cold Spring Harbor Perspectives in Medicine. November 9, 2016; Doi:10.1101\/cshperspect.a026179 (2016).<\/li>\n<li><a href=\"http:\/\/science.sciencemag.org\/content\/354\/6312\/549.full\">How tobacco smoke changes the (epi)genome<\/a>; Gerd P. Pfeifer; Science\u00a0 04 Nov 2016: Vol. 354, Issue 6312, pp. 549-550; DOI: 10.1126\/science.aal2114<\/li>\n<li><a href=\"http:\/\/science.sciencemag.org\/content\/253\/5015\/49\">p53 mutations in human cancers<\/a>; M Hollstein, D Sidransky, B Vogelstein, CC Harris; Science\u00a0 05 Jul 1991: Vol. 253, Issue 5015, pp. 49-53; DOI: 10.1126\/science.1905840<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><span style=\"color: #daa520;\">\u0628\u0631\u064a\u062f \u0627\u0644\u0643\u0627\u062a\u0628 \u0627\u0644\u0627\u0644\u0643\u062a\u0631\u0648\u0646\u064a<\/span>: <a href=\"mailto:redataha962@gmail.com\">redataha962@gmail.com<\/a><\/p>\n","protected":false},"featured_media":7722,"menu_order":1480,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[7410,5928,5797],"class_list":["post-14655","articles","type-articles","status-publish","has-post-thumbnail","hentry","tag-tag-1661","tag-tag-179","tag-tag-48"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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